Effect Of Raw Rhubarb Combined With Low-dose PGEP On Cleansing In The Intestinal Tract

Objective: To observe whether raw rhubarb can ensure intestinal cleanliness,reduce the total amount of intestinal fluids and the incidence of adverse reactions while improving the tolerance of subjects to intestinal cleaners when using raw rhubarb combined with low-dose polyethylene glycol electrolyte powder(PGEP)solution to clean intestinal tract before colonoscopy,and to investigate whether this method is superior to oral PGEP alone.Methods: 260 cases of subjects who were treated for colonoscopy at Affiliated Hospital of Hebei University of Engineering from December 2018 to November 2019 were selected,with four randomized groups of A,B,C and D,with group A as the control group and group B,C and D as the experimental group.Group A consisted of 64 patients(3L PGEP),group B consisted of 64 patients(500ml rhubarb extract + 2L PGEP),group C consisted of 65 patients(1L PGEP + 500 ml raw rhubarb extract + 1L PGEP),group D consisted of 67 patients(2L PGEP + 500 ml raw rhubarb extract).Oral method: the subjects in group A: 1 L PGEP solution was taken orally at 19:00 the day before colonoscopy,and 2 L PGEP solution was taken orally at 05:00-07:00 on the day of colonoscopy.The subjects in group B: 500 ml raw rhubarb extract was taken orally at 19:00 the day before colonoscopy,and 2 L PGEP solution was taken orally at 05:00-07:00 on the day of colonoscopy.The subjects in group C: 1 L PGEP solution was taken orally at 19:00 the day before colonoscopy,and 500 ml raw rhubarb extract +1 L PGEP solution was taken orally at 05:00-07:00 on the day of colonoscopy.the subjects in group D: 1 L PGEP solution was taken orally at 19:00 the day before colonoscopy,and 1 L PGEP solution+500ml raw rhubarb extract was taken orally at 05:00-07:00 on the day of colonoscopy.Comparing four groups of subjects with Ottawa bowel preparation scale(intestinal cleanliness score,total fluid score in the intestinal cavity),intestinal bubble content and visuality score,nighttime sleep(sleep duration,number of night defecations),the occurrence of uncomfortable symptoms(nausea,vomiting,dizziness,bloating,abdominal pain,heart palpitations,cold sweating,hunger).Willingness to take again,overall adverse reaction score and tolerability score.Results: 1.Intestinal cleanliness score in Ottawa bowel preparation scale: there was no difference between the colon assessment groups(P >0.05).Total fluid score in the intestinal cavity: group A was larger than group B and group C,with statistically significant difference(P<0.01).Group D was larger than group B and C,with statistically significant difference(P<0.01).There was no difference between groups A and D(P>0.05).2.Intestinal bubble content and visuality score: there was no difference between groups(P>0.05).3.nighttime sleep: Sleep duration: There was no difference between groups(P>0.05).Number of night bowel defecations: Group B was smaller than group A,C and D,with statistically significant difference(P<0.01).4.The occurrence of discomfort symptoms: rate of nausea,rate of vomiting,rate of bloating: Group A is greater than B,C,D,the difference is statistically significant(P<0.05);The incidence of dizziness,abdominal pain,palpitations,cold sweats and hunger: there was no difference between groups(P >0.05).5.Willingness to take again: B,C group is greater than Group A,D,the difference is not statistically significant(P>0.05).6.Overall Adverse Reaction Score and Toleration Score: Overall Adverse Reaction Score: A,D group is greater than B,C group,the difference is statistically significant(P<0.05).Tolerance score: A,D Group is larger than B,C Group,with statistically significant differences(P<0.05).Conclusions: 1.Subjects who had taken raw rhubarb combined with low-dose PGEP used for intestinal preparation had the same intestinal cleanliness score and a lower occurrence of discomfort symptoms than subjects who took oral PGEP alone.2.Subjects who had taken rhubarb on the day before colonoscopy and who had taken rhubarb first on the day of colonoscopy had less total intestinal fluid,less overall adverse reactions,better tolerance,and higher willingness to take again.Subjects who had taken rhubarb the day before colonoscopy had better nighttime sleep than the others.