Clinical Observation Of Acupoint Application Of Traditional Chinese Medicine In The Treatment Of Threatened Abortion Of Kidney Deficiency

Objective:In this subject,Shoutaiwan,a famous prescription for antiabortion were used to make the paste.Through clinical observation,the clinical efficacy of Acupoint Application of traditional Chinese medicine combined with progesterone intramuscular injection,didrogesterone tablets and Antai recipe in the treatment of threatened abortion with kidney deficiency was discussed,and its related factors was preliminarily explored from the aspects of endocrine factors,hemorheological factors and immune factors.Through this study,we try to provide more diversified treatment options for threatened abortion patients,and expand the clinical application of Acupoint Application of traditional Chinese medicine.Methods: In this study,the patients were randomly divided into two groups,40 cases in each group for 14 days.During the treatment period,the conventional treatment group was treated with progesterone injection,didrogesterone tablets and An Tai fang.The application loading group add Acupoint Application on the basis of the conventional treatment group.The pregnancy rate,TCM syndrome scores before and after treatment were counted.P,E2,HCG,coagulation function,blood viscosity,cytokines and uterine artery ultrasound were monitored.The results were analyzed by SPSS software.Results:1.The rate of continued pregnancy:The rate of continued pregnancy was 95% in both groups,and there was no statistical difference(P>0.05).2.TCM Syndrome Score:Compared before and after treatment,TCM Syndrome Score in both group decreased and had statistical significance(P<0.05).The application loading group was significantly lower than the conventional treatment group,with statistical significance(P<0.05).It showed that the TCM syndrome score of the two groups decreased significantly after treatment,the kidney deficiency symptoms improved,and the application loading was significantly lower than the conventional treatment group(P<0.05).The effect of application loading group was better than that of conventional treatment group,especially in improving abdominal pain or swelling.3.Total curative effect judgement:In comprehensive curative effect judgement,the marked efficiency of the application loading group was 86.8%,the non-marked efficiency was 13.2%,the marked efficiency of the conventional treatment group was 55.5%,the non-marked efficiency was 44.7%.The difference is great(P<0.05);in syndrome curative effect judgement,the healing rate of the application loading group was 0%,the marked efficiency was 18.4%,the effective rate was 81.6%,and the ineffective rate was 0%.The healing rate of the conventional treatment group was 0%,the marked efficiency was 7.9%,the effective rate was 68.4%,and the ineffective rate was 23.7%.The difference is great(P<0.05).The results showed that the application loading group was superior to the conventional treatment group in the comprehensive effect and syndrome effect.4.Relevant indicators of endocrine factors:1)The serum HCG doubling level of the two groups decreased with the change of time,but there was no great difference(P>0.05).There was great difference in the repeated measurement time between the two groups(P<0.05).2)Serum E2 levels in both groups increased with time,but there was no great difference(P>0.05).There was great difference between repeated measurements in each group(P<0.05).3)The serum P levels were not equal at different time points within the two groups(P<0.001),not between them(P>0.05).5.Relevant indexes of Hemorheology:1)Coagulation function,in APTT and D-dimer,the two groups were same before and after treatment(P>0.05);PT indexes of the two groups after treatment were shorter than before treatment,there was great difference within the group(P<0.05)not between(P>0.05).The Fg index of the two groups increased after treatment,there was great difference within the group(P<0.05),not between(P>0.05).2)After treatment,the whole blood viscosity of shear rate 1 and shear rate 30 in both groups decreased compared with that before treatment.Especially within the application loading group(P<0.05).In shear rate 200,there was no significant difference in blood viscosity both between groups and within groups(P>0.05).3)Uterine artery ultrasound showed that there was no significant difference in uterine artery deletion rate,S/D value and RI value between the two groups(P>0.05).6.Relevant indicators of immune factors:Cytokines: After treatment,the levels of IL-2 in both groups were lower than those before treatment(P>0.05).After treatment,the levels of IFN-gamma in both groups were higher than those before treatment(P>0.05).After treatment,TNF-alpha index was lower in the application loading group than before treatment,and increased in the conventional treatment group.There was no significant difference between groups and within groups(P>0.05);IL-6 index was higher in the application loading group after treatment than before treatment,and decreased in the conventional treatment group after treatment.There was no significant difference between groups and within groups(P>0.05).The levels of IL-10 in both groups decreased after treatment(P>0.05).7.Embryonic development:After treatment,the difference between the mean diameter of gestational sac and germ in the application loading group was greater than that in the conventional treatment group(P>0.05).In the application loading group,47.4% of the pregnant sacs were small,36.8% were medium and 15.8% were large.In the conventional treatment group,42.1% of the pregnant sacs were small,44.7% were medium and 13.2% were large.The composition of small,large and medium gestational sacs was the same in the two groups after treatment(P>0.05).After treatment,according to the small gestational sac,the difference between the average diameter of the gestational sac and the germ in the application loading group was larger than that in the conventional treatment group(P<0.05).At the same time,the proportion of the small gestational sac in the two groups was different after treatment(P<0.05).In the application loading group,mild accounted for 61.1%,moderate accounted for 38.9%,severe 0%.In the conventional treatment group,mild accounted for 31.3%,moderate accounted for 37.5%,severe accounted for 31.3%.After treatment,the difference between the mean diameter of the gestational sac and the germ of the large gestational sac group in the application loading group was smaller than that in the conventional treatment group(P>0.05).Conclusion: Acupoint application can effectively improve the symptoms of kidney deficiency in patients with threatened abortion of kidney deficiency,especially abdominal pain or dropping swelling.It can improve hemorheological indexes to some extent,reduce blood viscosity,and promote embryonic development,match the average diameter of gestational sac with the length of embryo,synchronize the growth of gestational sac and alleviate the degree of small gestational sac.Finally,the clinical comprehensive curative effect was improved,and the comprehensive effective rate was 86.8%.