Effect Of Noise Pollution On Neuroendocrine System In Rats

Objective: To study the effects of noise pollution on human physical and mental health,finding out the internal factors of tissue damage caused by noise pollution and prevent injury interventions.Wistar rats were used as experimental subjects to study the effects of noise pollution on the neuroendocrine system.To further explore the impact of noise pollution on human health,preventing and controlling noise pollution,and provideing environmental protection pollution standards for national environmental protection departments.Methods: SPF-level male Wistar rats were given different levels of noise stimulation,or intervention measures were given first,followed by the same noise stimulation.The blood of the noise-stimulated group and the control group were detected by ELISA(2),brain tissue nucleotides,catecholamine hormones,heat shock protein-70 levels.Results: 1.Wistar rats were placed in the noise pollution environment of 35 d B,65 d B and 85 d B for 20 days respectively.The level of noradrenaline(NA)in the blood of rats was increased by 28.22%,53.96% and 72.95%,respectively.The level of NA in the reserpine+85d B noise group was 7.49% lower than that in the control group;the level of adrenaline(A)was 33.69%,74.12%,and 87.73% higher than that in the control group,and the level of adrenaline in the reserpine+85d B noise group was higher.The control group decreased by 9.28%;the blood dopamine(DA)level in rats decreased by 15.32%,18.27%,and 24.71%,respectively,and the DA level in the reserpine+85d B noise group decreased by 27.65% compared with the control group.The difference in experimental results was significant(P< 0.01).2.The level of adenosine monophosphate in rats was 14.53%,36.29%,72.84%higher than that in the control group,and the level of cyclic adenosine monophosphate(c AMP)in the reserpine+85d B noise group was 6.32% higher than that in the control group..The level of guanosine monophosphate in rats was increased by 34.43%,66.64%,and 87.74%,respectively.The level of c GMP in the reserpine+85d B noise group was 11.68% lower than that in the control group.The difference in experimental results was significant(P<0.01).3.Rats were placed in a noise-contaminated environment with 35 d B,65 d B,and85 d B intensity for 20 days.The expression of c-fos in the frontal cortex,hippocampus,striatum,nucleus accumbens,thalamus and amygdala was detected in rat brain tissue.The level was significantly higher than that of the control group,and increased with the increase of noise stimulation intensity,the difference was significant(P<0.01).The expression level of c-fos in the reserpine group was higher than that of the control group,but compared with the stimulation group obvious reduction.The expression level of heat shock protein-70(Hsp-70)in rat brain was significantly higher than that in the control group.The expression level of heat shock protein-70(Hsp-70)in the reserpine group was significantly lower than that in the noise-contaminated group.Conclusion: The experimental results show that noise pollution can significantly affect the synthesis and secretion of endocrine hormones in the body,and the expression of c-fos and Hsp-70 in brain tissue is significantly increased.Noradrenaline(NA)is the main factor damage caused by noise pollution.Reserpine reduces or depletes norepinephrine levels.Noise(35d B)below the ambient noise 0class standard intensity can also cause abnormal hormone levels and protein expression in the body and cause damage to the body.The experimental results provide a reference for the revision of noise pollution standards.