The Effects Of Aerobic Exercise And High Fat Diet On Adipose Triglyceride Lipase Expression In Mice Skeletal Muscle

Objectives:We observer the effects of aerobic exercise and high fat diet on adipose triglyceride lipase(ATGL)expression in mice skeletal muscle and the index of blood to investigated the mechanism of effects of exercise on lipid metabolism.Methods:40 eight-weeks old male mice were divided into control diet and rest group(N=10),control diet and exercise group(N=10),high fat diet and rest group(N=10),high fat diet and exercise group(N=10)randomly.After 8 weeks Treadmill training,we tested the value of soleus ATGL protein,blood serum glucose,insulin,Homeostasis model assessment-Isulin Resistance.Results:(1)High fat diet and aerobic exercise made the effect of reciprocal inhibition on weight and fat/weight.HF+C group mice's weight The fat/weight were significant higher than C and HF+EX groups(p<0.01).(2)The high fat diet promoted the serum glucose,insulin and the HOMA-IR.The serum glucose of HF+EX group mice's were significant higher than the C+EX group(p<0.05).The serum insulin of HF+C group mice's were significant higher than the C group(p<0.01).The HOMA-IR of HF+C group mice's were significant higher than the C group(p<0.05).The HOMA-IR of HF+EX group mice's were significant higher than the C+EX group(p<0.01).(3)Aerobic exercise improved the value of skeletal muscle's ATGL.The ATGL of the HF+EX group were significant higher than the HF+C group(p<0.05).Conclusions:(1)High fat diet will increased the mice's weight,fat/weight,aerobic exercise can reversed these situations.Aerobic exercise and high fat diet are reciprocal inhibition.(2)High fat diet will increased the mice's serum glucose,HOMA-IR.HOMA-IR and weight,fat/weight were positive correlation.(3)Aerobic can increased the expression of skeletal muscle ATGL,ATGL regulated the lipid metabolism of skeletal muscle.