Research On The Syndrome Types Of Sjogren's Syndrome Combined With Leukopenia

Purpose:Through a retrospective analysis of the clinical data of 92 cases of SS with leukopenia,To explore the distribution characteristics of TCM syndrome types and their correlation with patients’ general data,clinical manifestations,laboratory indicators,etc.,so as to provide some evidence-based medicine basis for clinical guidance.Material and method:From January 2013 to December 2019,patients with Sjogren’s syndrome and leukopenia in rheumatology department of Affiliated Hospital of Liaoning University of traditional Chinese medicine were collected.Strictly abide by the inclusion and exclusion criteria,classify and sort out the data according to the syndrome type,establish a database,sort out and summarize by statistical methods,explore the correlation between TCM syndrome type and patients’ general information,clinical performance,laboratory indicators,etc.,and finally come to a conclusion.Results:1.92 patients with Sjogren’s syndrome and leukopenia are included,including 0 male and 92 female.2.The number and frequency of five types of syndrome are: deficiency of Qi and Yin(49 /53%),stagnation of phlegm and blood stasis(21 / 23%),deficiency of liver and kidney yin(9/ 10%),damp heat retention(7 / 8%),yin deficiency and heat toxin(6 / 6%).3.The age of onset is 78 years old,and the age of onset is 27 years old.There is no significant difference among the five groups(P > 0.05);the age of onset is 30 years,and the age of onset is half a year.There is significant difference among the five groups(P < 0.05).The duration of liver kidney yin deficiency syndrome is longer,with an average of 14.00 ± 10.33 years,and the duration of damp heat syndrome is shorter,with an average of 3.43 ± 2.70 years.4.There are statistically significant differences in the symptoms of joint pain,shortness of breath,night sweat,dry skin,and sore waist and knees among the five groups(P < 0.05),while there is no statistically significant difference among the other groups(P > 0.05).5.The difference of WBC reduction among different syndrome types is statistically significant(P < 0.05).The most obvious effect on WBC reduction is damp heat syndrome(3.17 ± 0.43 * 109 / L),the least obvious is Qi Yin deficiency syndrome(3.57 ± 0.35 *109 / L).6.There is significant difference between ESR group and CRP group(P < 0.05).The meanvalue of ESR and CRP in the phlegm stasis syndrome group is the highest,34.71 ±21.00mm/h and 9.70 ± 10.50mg/l respectively;the mean value of ESR and CRP in the damp heat syndrome group is the lowest,13.00 ± 11.34mm/h and 1.66 ± 1.89mg/l respectively.There is no significant difference in RF group(P > 0.05).7.There is no significant difference between Ig A group and Ig M group in each syndrome type(P > 0.05);there is significant difference in Ig G between the five groups(P < 0.05),and the mean value of damp heat syndrome was the highest(21.53 ± 6.30 g / L).The second is Qi Yin deficiency(20.56 ± 5.12 g / L).8.There is significant difference between the two groups(P < 0.05).Among them,the positive rate of anti SSA in phlegm stasis syndrome was the highest(100%);the positive rate of anti SSB in damp heat syndrome was the highest(71.4%),followed by Yin deficiency and heat toxin syndrome(66.7%).There is no difference in the positive rate of anti-ro-52 antibody between different syndromes(P > 0.05).Conclusion:1.Sjogren’s Syndrome combined with leukopenia,the frequency of TCM syndrome type from high to low is: Qi Yin deficiency syndrome,phlegm stasis syndrome,liver kidney yin deficiency syndrome,yin deficiency heat toxin syndrome,damp heat retention syndrome.2.The longer the course of disease,the more likely the deficiency of liver and kidney yin,and the shorter the course of disease,the more likely the damp heat syndrome.3.The most obvious effect on leukopenia is damp heat retention syndrome,and the least obvious is Qi Yin deficiency syndrome.4.The most obvious effect on the rise of ESR and CRP is phlegm stasis syndrome,and the least obvious is damp heat syndrome.5.Ig G increased most obviously in damp heat retention syndrome,followed by Qi Yin deficiency syndrome;IgA group and IgM group had no effect on syndrome type.6.The positive of anti SSA antibody is more likely to appear in the syndrome of stagnation of phlegm and blood stasis;the positive of anti SSB antibody is more likely to appear in the syndrome of yin deficiency and heat toxin and the syndrome of dampness and heat accumulation.