A Retrospective Cohort Study And Survival Analysis Of Stage ?/? Ovarian Cancer Treated With Traditional Chinese Medicine

ObjectiveIn this study,we sought to select the risk and protective factors of stage ? or ? ovarian cancer and explore the effective treatment by analyzing the effect of traditional Chinese medicine(TCM)on stage ? or ? ovarian cancer survival,comparing by stages and groups and studying the prognosis of various indicators.MethodsWe performed a retrospective study via outpatient and telephone follow-up.236 women who underwent stage ? or ? ovarian cancer and made their first visit to Cancer Hospital Chinese Academy of Medical Sciences during January 1,2015 to December 31,2016 were included in the study,as of December 31,2019,.According to the degree of exposure treated by TCM,they are divided into high exposure group,low exposure group and no exposure group.We used the Kaplan-Meier method and Cox proportional hazards models to analyse their overall survival(OS)and progression-free survival(PFS)and study the relationship between age,BMI,the times of menopause and pregnancy,past history,family history of malignant tumor,level of CA125,ascites,tumor growth,pathological type,Distant metastasis,FIGO stage,Surgery,chemotherapy,targeted therapy,TCM treatment and prognosis of patients with stage? or ? ovarian cancer.We also used R software to establish prediction models for independent factors and verify them.Results1.As of December 31,2019,90(38%)died of the 236 patients,and the 3-year cumulative survival rates were 65.2%,respectively.174 cases(74%)relapsed.The 1-year and 3-year cumulative PFS were 86.9%and 31.2%,respectively.2.According to the degree of exposure,there were 79 cases in high exposure group,83 cases in low exposure and 74 cases in non-exposure.The results of Kaplan-Meier analysis showed that the high exposure group could improve PFS and OS of patients with stage ? or ?ovarian cancer,with best long-term effect(P<0.05),while there was no significant difference between low exposure and non-exposure group.3.In univariable analysis,menopause,clinical stage,satisfactory tumor reduction surgery,ascites,distant metastasis,neoadjuvant chemotherapy,postoperative chemotherapy course and dialectical decoction treatment were related to PFS and OS.Additionally,initial BMI and history of diabetes were related to PFS,and targeted therapy is associated with OS.(P<0.05)4.In Multivariate ana Univariate analysis showed that:whether menopause,satisfactory tumor reduction,distant metastasis,neoadjuvant chemotherapy,clinical staging,postoperative chemotherapy treatment,the presence of ascites,and the presence or absence of decoction therapy are related to PFS and OS.In addition,initial treatment of BMI is associated with diabetes and PFS,and targeted therapy is associated with OS.(P<0.05)5.We established a 3-year progression-free survival rate and a 3-year survival rate prediction model,and the consistency indexes were 0.744 and 0.751,respectively.ConclusionThis study established a preliminary prediction model of 3-year progression-free survival rate and 3-year survival rate,we found that patients might reduce the recurrence rate of stage ?or ? ovarian cancer and improve the survival rate by high exposure and adhere to integrated treatment of Chinese and western medicine for more than one year.