The Investigation Of The Ancient And Modern Application And Preliminary Study On The Activity Of The Medicines And Foods Of The Same Kind Of Medicine To Assist In Lowering Blood Sugar

Diabetes mellitus is an endocrine and metabolic syndrome characterized by hyperglycemia and a genetic predisposition.Its global morbidity continues to increase,causing a high mortality of cardiovascular and cerebrovascular diseases,which seriously threatens human health.Oral drug intervention is mainly used for clinical treatment of diabetes,especially type II diabetes Commonly used chemical drugs will produce a series of adverse reactions.Therefore,it is an urgent problem to find a treatment method with less adverse reactions and good hypoglycemic effect.The idea of "homology of medicine and food"has a long history in China.The Chinese medicine of them are less toxic and safe to use,and a large number of which have a hypoglycemic effect.With developing attention to health issues,auxiliary hypoglycemic products ha've also gained society.In March 2018,the State Administration of Market Supervision made an announcement,which mentioned that "the auxiliary hypoglycemic function needs to continue to be demonstrated".And also issued a tender notice for related topics,which reflects the importance that various sectors of society attach to the function of assisting hypoglycemia,and the need for further researchTherefore,this paper systematically sorts out the basic concepts and historical evolution of "homology of medicine and food" based on ancient medical books,and combined with the"homology of medicine and food" directory and related research literature published by the former National Health Commission to help reduce blood sugar.The "homology of medicine and food" Chinese medicine are discussed in ancient and modern times,and the "homology of medicine and food" Chinese medicine that have been researched and used more often are used to reduce blood sugar.The enzyme inhibits the reaction and evaluates the hypoglycemic activity in vitro.The necessity of a function provides theoretical support.The main findings are as follows:1?China has a long history of "homology of medicine and food" and is closely related to multidisciplinary development."Homology of medicine and food" substances are currently defined as:"Substances that are both food and Chinese medicinal materials according to tradition are those that have traditional eating habits and are included in national standards for Chinese medicinal materials(including animals and plants in)can be used(including food ingredients,spices and condiments)."This idea began in the prehistoric period and originated from Shen Nong.It was continuously improved and improved during the Qin and Han,Tang,Song,Jin,Yuan,and Ming and Qing Dynasties.Development is inseparable from the multidisciplinary development of economy,system,religion,and philosophy in each era.While developing itself,it also absorbs overseas cultural and medical knowledge,which is closely related to the degree of openness and communication in China.2?In ancient China,there was rich research on diabetes,and the use of "medicinal and food homologous" medicinal materials accorded with Chinese medicine's understanding of etiology and pathogenesis.Since the Tang Dynasty,ancient Chinese doctors and medical scientists have begun to systematically treat thirst and form a certain treatment method.With the continuous increase of the types of drugs and the in-depth understanding of its etiology and pathogenesis,combined with the historical background,it concludes different prescriptions have been developed for the treatment of thirst.In the course of treatment,the main treatments are tonicity,clearing heat and resolving the table,supplemented by water soaking,divergence and astringency,etc.Therefore,the ancient Chinese medicine and food of the same origin for the treatment of thirst are also mainly concentrated on tonic medicines,antipyretics,astringent medicines and other types of medicinal materials,ranked according to the frequency of occurrence,the first few are Glycyrrhizae Radix et Rhizoma?Ginseng Radix et Rhizoma?Poria?Astragali Radix?Puerariae Lobatae Radix?Cinnamomi Cortex.3?The types of auxiliary hypoglycemic products are relatively concentrated with the main raw materials,and are also affected by relevant policies and regulations.At present,most auxiliary hypoglycemic products on the market are from the perspective of the audience and consumers.Most of the dosage forms are capsules and tablets that are easy to use and highly patient-compliant,and other dosage forms are used less.Different from ancient China,the focus is mainly on Mori Folium?Astragali Radix?Puerariae Lobatae Radix?Propolis?Dioscoreae Rhizoma and Panacis Quinquefolii Radix.Most of its saponin and flavonoids are used to reduce blood sugar.However,the approval of the product to be listed on the market has been affected by the relevant regulations issued by the State Market Supervision and Administration Administration.In recent years,the release of new products has been stagnant.4?Fundamental research on traditional Chinese medicine that assist in blood sugar reduction has continued to increase,and there is still great potential for follow-up.From 1976 to 2019,the number of research literatures on "homology of medicine and food" Chinese medicine that assisted in lowering blood glucose has been growing in twists and turns,and the research topics have focused on the decline of Mori Folium?Ginseng Radix et Rhizoma?Astragali Radix?Puerariae Lobatae Radix?Dioscoreae Rhizoma and Ganoderma.The hypoglycemic effect of Dendrobii Officinalis Caulis may be a research hotspot at present and in the future.At the same time,the antioxidant,hypolipidemic,and weight-regulating effects of traditional Chinese medicines that assist in lowering blood sugar are also receiving more and more attention.5?Astragalus membranaceus(Fisch.)Bge.,Morus alba L.and Pueraria lobata(Willd.)Ohwi have strong in vitro enzyme inhibitory activity and can be used as important raw materials for future related products.Panax quinquefolium L.,Pueraria lobata(Willd.)Ohwi,Astragalus membranaceus(Fisch.)Bge.,Morus alba L.,Apismellifera L.,Fagopyrum dibotrys(D.Don)Ham,6 kinds of Chinese herbal medicine extracts ?-glucosidase,?-amylase and dipeptidyl peptidase ?(DPP-4)all have inhibitory effects,and the inhibition rate increases with the increase of the extract The order of inhibition of various raw materials on ?-glucosidase is Morus alba L.>Astragalus membranaceus(Fisch.)Bge.>Pueraria lobata(Willd.)Ohwi>Apismellifera L.>Fagopyrum dibotrys(D.Don)Ham>Panax quinquefolium L.,order of magnitude of inhibition on a-amylase For:Astragalus membranaceus(Fisch.)Bge.>Fagopyrum dibotrys(D.Don)Ham>Pueraria lobata(Willd.)Ohwi>Morus alba L.>Panax quinquefolium L.>Apismellifera L.,p-peptidyl peptidase ?(DPP-4)the order of inhibition is:Morus alba L.>Astragalus membranaceus(Fisch.)Bge.>Pueraria lobata(Willd.)Ohwi>Apismellifera L.>Fagopyrum dibotrys(D.Don)Ham>Panax quinquefolium L..By comparing with the raw materials of auxiliary hypoglycemic products available in the market,a comprehensive analysis can conclude that Astragalus membranaceus(Fisch.)Bge.,Morus alba L.and Pueraria lobata(Willd.)Ohwi have good hypoglycemic activity,which can be used as Potential raw materials for product development continue to be studied in depth.