Study And Preliminary Clinical Value Analysis Of The Relationship Between Episclera Venous Pressure And Intraocular Pressure In TAO Patients

Objective:1.To clarify the relationship between intraocular pressure and episclera venous pressure in TAO patients;2.To provide some clinical basis for the assessment of TAO patients with intraocular pressure;3.To observe the clinical characteristics of optic nerve injury in patients with TAO accompanied by increased intraocular pressure.Methods:Retrospective randomized controlled trial was used in this study.The experimental group:30 eyes of 15 patients diagnosed with TAO with exophthalmus;Control group:28 eyes of 14 healthy people who were randomly selected;The measurement of exophthalmos,episclera venous pressure,intraocular pressure and optic fiber layer thickness be performed respectively,the function of the optic fiber be watched through the visual field.Compare the differences of episclera venous pressure,and changes in intraocular pressure between the experimental group and the control group respectively.Analysis of variance and t-test were used to compare the difference of episclera venous pressure and intraocular pressure between the experimental group and the control group,to further analyze the relationship between intraocular pressure and episclera venous pressure.Observe the clinical characteristics of increased episclera venous pressure on optic nerve injury.Results:The following results were obtained by monitoring the exophthalmos,episclera venous pressure and intraocular pressure,thickness of optic nerve fiber layer and visual field in TAO patients and normal people:(1)The superior scleral venous pressure in the experimental group was significantly higher than that in the control group(P<0.001);(2)The intraocular pressure in the experimental group was significantly higher than that in the control group(P<0.001);(3)There was a positive linear correlation between the episclera venous pressure(y)and the intraocular pressure(x)in the experimental group:y=0.9684 x+3.737(RS>0,P<0.05);(4)The increase of episclera venous pressure was earlier than intraocular pressure in the experimental group;(5)There was a positive linear correlation between scleral venous pressure(y)and exophthalmos(x)in the experimental group 691(RS>0,P<0.05);(6)There was no clear correlation between the increase of episclera venous pressure and the thickness of optic nerve fiber layer;(7)Some TAO patients with elevated intraocular pressure had clinical manifestations of optic nerve function damage.Conclusion:1.Elevated orbital pressure was an important factor leading to increased intraocular pressure in TAO patients,which showed a positive linear relationship between episclera venous pressure and intraocular pressure;2.The increase of episclera venous pressure was earlier than that of intraocular pressure,indicating the increase of orbital pressure,which could be used as an indicator of early clinical intervention in TAO patients.3.Protrusion can be used as one of the quantitative indicators for the evaluation of orbital pressure,which showed a positive linear correlation with episclera venous pressure.4.Some patients with high intraocular pressure of TAO have the condition of optic nerve fiber layer damage,which is at the risk of developing secondary glaucoma and permanently damage of the optic nerve fiber.