| Objective: To explore the clinical efficacy of Jianpi Kaiwei Recipe in treating colorectal cancer patients with gastrointestinal symptoms(spleen and stomach Qi deficiency syndrome)after chemotherapy.Methods:According to the random number table method,60 patients with colorectal cancer were divided into treatment group and control group,with30 cases in each group.Both groups of patients were treated with XELOX chemotherapy.Control group: Treat symptomatically and supportively with western medicine;Treatment group: Orally take the Jianpi Kaiwei recipe on the basis of the control group and continue to take it until the end of chemotherapy.Compare the two groups of patients with digestive system toxicity such as nausea,vomiting,diarrhea,constipation,TCM syndrome score,cassette score,tumor markers CEA,CA19-9,white blood cells,neutrophils,hemoglobin,platelets and other blood system toxins The side effects,alanine aminotransferase,creatinine and other indicators of liver and kidney function toxicity and side effects were analyzed by statistics.Results:(1)Take the intravenous infusion of oxaliplatin for injection as the time baseline on the first day of medication,and select 3 time points,namely D1(the first day after the medication),D9(the 9th day after the medication),and D21(the medication On the 21 st day later),observe and compare the changes in the gastrointestinal toxicity of the two groups,such as nausea,vomiting,diarrhea,and constipation.Comparison of nausea and vomiting,diarrhea,and constipation between the two groups on D1 was not statistically significant and comparable(P>0.05);comparison of nausea and vomiting,diarrhea,and constipation between the two groups on D9 was statistically significant(P<0.05),the treatment group The curative effect was better than that of the control group.There was no statistically significant difference in the comparison of nausea,vomiting,diarrhea,and constipation between the D21 two groups(P>0.05),and the two groups had the same curative effect.(2)The comparison of TCM syndrome scores between the two groups on D1 was not statistically significant and comparable(P>0.05);the comparison of TCM syndrome scores between the D9 and D21 groups was statistically significant(P<0.05).The total effective rate of TCM syndrome score improvement in the D9 treatment group was 83.33%,and that of the control group was 56.66%,the difference was statistically significant(P<0.05).The total effective rate of improvement of TCM syndrome scores in the D21 treatment group was93.33%,and that of the control group was 63.33%,the difference was statistically significant(P<0.05).(3)Comparing the cassette scores between the two groups in D1,the difference was not statistically significant and comparable(P>0.05);the effective rate of cassette score improvement in the D9 treatment group was 73.33%,and that of the control group was 50.00%.The difference was statistically significant.Scientific significance(P<0.05);The effective rate of improvement of Cassette score was 93.33% in the D21 treatment group and 66.66% in the control group.The difference was statistically significant(P<0.05).(4)The CEA comparison between the two groups on D1 was not statistically significant(P>0.05);the CEA comparison between the two groups on D21 was not statistically significant(P>0.05);there was no statistical significance between the D1 and D21 treatment groups and the control group(P> 0.05).The comparison of CA19-9 between the two groups of D1 was not statistically significant(P>0.05);the comparison of CA19-9 between the two groups of D21 was not statistically significant(P>0.05);there was no statistical significance between the D1 and D21 treatment groups and the control group(P>0.05).(5)Comparison of white blood cells,neutrophils,hemoglobin,and platelets between the D1 two groups was not statistically significant(P>0.05)and comparable;D21 two groups of white blood cells,neutrophils,hemoglobin,and platelets were compared,there was no difference Statistically significant(P>0.05).(6)The comparison of alanine aminotransferase and creatinine between the two groups on D1 was not statistically significant(P>0.05)and was comparable;the difference between the alanine aminotransferase and creatinine of the D21 two groups was not statistically significant(P>0.05).(7)No adverse reactions were observed in the digestive tract symptoms of patients with colorectal cancer after taking Jianpi Kaiwei Decoction.Conclusion:(1)Jianpi Kaiwei Decoction can improve the digestive tract symptoms of patients with colorectal cancer after chemotherapy,and alleviate the suffering of patients;(2)Jianpi Kaiwei Recipe can improve the scores of TCM syndromes of patients and the cassette scores of patients,and improve the quality of life of patients;(3)Jianpi Kaiwei Recipe cannot improve the tumor markers CEA and CA19-9 in patients with colorectal cancer;(4)Jianpi Kaiwei Recipe has no obvious blood system toxicity and liver and kidney function toxicity;(5)Jianpi Kaiwei Decoction can be promoted clinically to relieve gastrointestinal symptoms of patients with colorectal cancer after chemotherapy. |
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