| Objective: Through the method of randomized controlled study to evaluate the clinical efficacy of Sishen Wan combined with Shenling Baizhu San in the treatment of ulcerative colitis of spleen kidney yang deficiency type,and provide selection and basis for clinical treatment and efficacy evaluation of ulcerative colitis of spleen kidney yang deficiency type.Methods: 68 patients with ulcerative colitis of spleen and kidney yang deficiency type in Anhui provincial hospital of traditional Chinese medicine from October 2019 to December 2020 were selected and divided into observation group(Sishen Wan combined with Shenling Baizhu San group)and control group(mesalazine group),34 cases in each group.The treatment lasted for 8 weeks.The comprehensive efficacy,modified Mayo score,Baron endoscopic UC activity grading score,ESR level,CRP level,TCM symptom score and TCM syndrome efficacy of the two groups before and after treatment were observed and recorded.The efficacy of different treatment schemes was evaluated and statistically analyzed,and the drug safety was monitored.Results:(1)In this study,68 patients with ulcerative colitis of spleen kidney yang deficiency type were included.Due to patient compliance and other reasons,2 patients in the observation group were excluded(not treated according to the experimental method),5 patients fell off(withdrawn due to the epidemic situation),3 patients in the control group were excluded(not treated according to the experimental method),3patients fell off(withdrawn due to the epidemic situation),and 27 patients in the observation group and 28 patients in the control group were finally completed,There were 55 cases.There was no significant difference in age,gender,course of disease,condition and location between the two groups(P> 0.05).(2)The total effective rate of the observation group after treatment was 92.59%,9 patients were in complete remission,16 patients were effective,and 2 patients were ineffective.After treatment,the total effective rate of the control group was 82.14%,the total remission rate was 3,the effective rate was 20,and the ineffective rate was 5.After treatment,the curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).(3)There were significant differences in modified Mayo score between the two groups before and after treatment(P<0.05),and the observation group was better than the control group after treatment(P<0.05).(4)The Baron grading scores of the two groups were compared before and after treatment(P<0.05),and the observation group was better than the control group after treatment(P<0.05).(5)ESR and CRP values of the two groups were statistically significant(P<0.05)before and after treatment,and the observation group was better than the control group after treatment,with significant difference(P<0.05).(6)The total effective rate of the observation group after treatment was 88.89,2 patients were in clinical remission,9 patients were markedly effective,13 patients were effective and 3patients were ineffective.After treatment,the total effective rate of the control group was 78.57,the clinical remission rate was 1,the markedly effective rate was 3,the effective rate was 18,and the ineffective rate was 6.After treatment,the curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).(7)Before and after treatment,the TCM symptom scores of the two groups were statistically significant(P<0.05),and the observation group was better than the control group in abdominal pain,anorexia and abdominal distension(P<0.05),but there was no significant difference in diarrhea,mucus purulent bloody stool and cold limbs(P>0.05).(8)During the treatment,one case of stomach distension and pain discomfort occurred in the observation group,which was improved after symptomatic treatment,and did not affect the follow-up treatment.There was no discomfort in the control group.Conclusion:For patients with ulcerative colitis of spleen and kidney yang deficiency type,Sishen Wan combined with Shenling Baizhu San combined with mesalazine is better than simple mesalazine treatment,which can effectively improve the comprehensive curative effect,reduce Mayo disease score,improve mucosal healing,reduce serum inflammatory index level,and improve the curative effect of traditional Chinese medicine syndrome.It has reliable clinical value and is worthy of further mechanism research and promotion. |
PDF Full Text Request