The Clinical Significance Of Ultrasound Evaluation Of Aortic Isthmus,umbilical Artery Blood Flow Parameters And Right Ventricular Tei Index In Fetuses Of Patients With Preeclampsia

Objective Application of CDFI to monitor the aortic isthmus（AOI）,umbilical artery（UA）blood flow parameters and right heart function in fetuses of pregnant women with preeclampsia（PE）,and to provide a evidence for perinatal management of pregnant women with PE and their fetuses.Methods 124 fetuses of 28～41⁺⁶ weeks in our hospital were selected and divided into a normal control group（60 cases）,a mild PE group（33 cases）,and a severe PE group（31 cases）.Peak systolic velocity（PSV）,end diastolic velocity（EDV）,pulsatility index（PI）,the systolic/diastolic ratio（S/D）of umbilical artery,and the peak systolic velocity（PSV）of AOI,systolic nadir（Ns）were obtained via pulse wave Doppler imaging（PW）,and isthmic systolic index（ISI）was calculated by dividing Ns with PSV.Then right ventricular isovolumic contraction time（ICT）,isovolumic relaxation time（IRT）,and ejection time（ET）were obtained via Tissue Doppler imaging（TDI）.Tei index was derived from the ratio of（ICT+IRT）/ET.Data were analyzed using SPSS 23.0 statistical software,all measurement data are expressed as Mean±Standard deviation（x±s）,analysis of variance was used for analysis of variance among different groups.Pearson correlation analysis was used for correlation analysis,test levelα=0.05,P<0.05 indicates that the difference is statistically significant.Results Aortic isthmus PSV,Ns,ISI in the mild and severe PE groups were lower than that in the control group,and aortic isthmus PSV,Ns,ISI in the severe PE groups was lower than that in the mild preeclampsia group,The differences were statistically significant（P<0.05）.Umbilical artery PSV,EDV in the mild and severe PE groups were lower than those in the control group,PSV,EDV in the severe PE group were lower than those in the mild PE group.Umbilical artery PI,S/D in the mild and severe PE groups were higher than those in the control group;PI,S/D in the severe PE group were higher than those in the mild PE group,the differences were statistically significant（P<0.05）.Right ventricular Tei index in the mild and severe PE groups were higher than that in the control group.Moreover,right ventricular Tei index in the severe PE group were higher than that in the mild PE group,the differences were statistically significant（P<0.05）.Meanwhile,negative correlation between right ventricular Tei index and isthmus systolic index（r=-0.54,P<0.05）.Conclusions The combined assessment of aortic isthmus,umbilical artery blood flow parameters and right ventricular Tei index can timely and effectively reflect the fetal intrauterine condition to reduce unnecessary iatrogenic preterm birth and guide clinicians to intervene as soon as possible to achieve good pregnancy outcomes.