Meta Analysis Of Complementary Feeding In Early Life And The Risk Of Allergic Diseases In Children

Objective:To systematically evaluate the effects of complementary feeding（CF）in early life and the risk of allergic diseases in children.Methods:Wanfang,CNKI,CBM,Cochrane library,Pub Med,Web of science and Embase databases were used to search the studies on CF and allergic diseases in children.Evaluators screened the literature,extracted data and evaluated the risk of bias in the study.Meta analysis was performed with Revman 5.3.The publication offset was tested by Egger with Stata 16.0.Results:1.Finally,22 literature were included,15 cohort studies and 7 randomized controlled trials.2.The results sho₃wed that there was no statistical significance between the timing of CF and the risk of developing atopic dermatitis in children.The results of subgroup analysis showed that at age≥4 months and<4 months,CF was not related to the risk of atopic dermatitis in children.At age≥6 months and<6 months,CF was not related to the risk of atopic dermatitis in children.At age>6 months and≤6 months,CF was not related to the risk of atopic dermatitis in children.3.The results showed that there was no statistical significance between the timing of CF and the risk of developing food allergy in children.But studies on CF and the risk of food allergy in children were heterogeneous.Subgroup analysis showed that CF was not related in the risk of food allergy at age≥4 months and<4 months.The CF could increase the risk of food allergy at age<6 months.The CF was not related in the risk of food allergy at age>6 months and≤6 months.The above results are different.Since the<6months and≥6 months group studies were from Asia,the<4 months and≥4 months,6 months and 6 months group studies were from Europe、America and Oceania.We did a Further subgroup analysis of the study in area.In Asia,early addition of supplementary food could increase the risk of food allergy,but in Europe,America and Oceania,The CF was not related in the risk of food allergy in children.4.The risk of different supplementary foods and allergic diseases showed that introducing egg before 6 months and peanut at 4-11 months reduced the risk of food allergy.There was no statistical significance between the timing of introducing fish and the risk of developing atopic dermatitis in children at age>6 months and≤6 months.Conclusions:1.There is no relationship between the age at which CF first begins and the risk of developing atopic dermatitis.2.There is no relationship between the age at which CF first begins and the risk of developing food allergy.However,there is great heterogeneity in the study,and regional differences are considered to be the main reason.3.Adding eggs b₄efore 6 months old and adding peanut at 4-11 months old could reduce the risk of food allergy in children.There is no relationship between the age at fish first begins and the risk of developing atopic dermatitis at age>6 months and≤6 months.