Clinical Observation On The Curative Effect Of Bushen Qiangjinzhibi Decoction In The Treatment Of Ankylosing Spondylitis （Cold Dampness Obstruction Syndrome）

Objective: By observing the clinical efficacy of Bushen Qiangjin Zhibi Decoction and Erbi Capsules plus etoricoxib in the treatment of ankylosing spondylitis（cold dampness obstruction syndrome）,the current progress in diagnosis and treatment of ankylosing spondylitis was summarized,and the comparative study of Bushen Qiangjin Clinical efficacy and therapeutic mechanism of Zhibi Decoction and Erbi Capsule on ankylosing spondylitis.To provide a theoretical basis for promoting Bushen Qiang Jin Zhi Bi Decoction in the treatment of ankylosing spondylitis（cold dampness obstruction syndrome）.Methods: From November 2019 to November 2021,68 patients who met the diagnostic criteria of ankylosing spondylitis（cold-dampness obstruction syndrome）from the Department of Orthopedics and Traumatology Clinic of Guanggu Branch of Hubei Provincial Hospital of Traditional Chinese Medicine were divided into a treatment group and a control group（34 persons in each group）according to the patient’s last foour clinic number.Treatment group:（1）Oral administration of "Bushen Qiangjin Zhibi Decoction "（recipe:30 grams of fried Atractylodes,15 grams of Morinda officinalis,15 grams of Epimedium,15 grams of Achyranthes from sichuan,12grams of Eucommia ulmoides,15 grams of Cortex Phellodendri,15 grams of Paeony,12 grams of Angelica,10 grams of black snake,3 grams of whole scorpion,12 grams of Yinchen.Usage: Decoct in water,one dose per day,400 ml per dose,once in the morning and once in the evening,200 ml each time,uniformly boiled from Hubei Provincial Hospital of Traditional Chinese Medicine）.（2）Oral administration of Enterotoxin Tablets（Qi Mingshu,Qilu Pharmaceutical Co.,Ltd.,approved by Chinese medicine H20193273）,60 mg,once a day.Stop taking the medicine after 1 week.Control group:（1）Oral administration of "Wangbi Jiaonang"（Liaoning China Resources Benxi Sanyao Co.,Ltd.,Z20080096）5 capsules at a time,3 times a day.（2）Oral Enterotoxin Tablets（Qi Mingshu,Qilu Pharmaceutical Co.,Ltd.,approved by Chinese medicine H20193273）,60 mg,once a day.Stop taking the medicine after 1week.The treatment cycle of the two groups was three months,and the general information,laboratory test results（erythrocyte sedimentation rate,C-reactive protein）,nighttime pain VAS score,BASDAI score,and spinal range of motion（Schober test,fingertips）were observed and recorded.Ground distance,pillow-wall distance),TCM syndrome scores and other indicators.Statistical data of other patients were processed by SPSS 26.0 software,and t-test was used for measurement data that conformed to normal distribution in each group.The results were expressed as mean ±standard deviation（x ±s）.Nonparametric test was used for cases that did not conform to the normal distribution;chi-square test was used for count data.Results:1.The nocturnal pain VAS score,BASDAI score,spinal mobility（Schober test,finger-to-ground distance,pillow-to-wall distance）,TCM syndrome scores and other indicators of the two groups of patients were compared before treatment,P value>0.05,no statistical analysis study meaning.2.During the three-month observation period,1 patient in the treatment group took other drugs by mistake,which affected the treatment effect;there were2 patients who did not go to the outpatient clinic in time for follow-up and no results were obtained after telephone contact,and the above 3 patients were excluded.2 patients in the control group were excluded due to personal reasons who were unable to return for consultation on time.All patients’ blood routine,urine routine,stool routine,liver and kidney function and other safety indicators did not change significantly after regular review,and all patients did not have obvious serious gastrointestinal reactions and other discomfort within a course of treatment.3.The comparison of the efficacy indicators between the two groups before treatment,P value>0.05,does not have statistical significance,after treatment,the comparison between the two groups,P value <0.05,the difference in efficacy indicators is statistically significant.4.The overall effective rate of the treatment group was 93.55%,while the overall effective rate of the control group was 71.88%.Through statistical comparison Z=-3.238,P value=0.001（P<0.05）,the difference in the efficacy of traditional Chinese medicine was statistically significant.Conclusion: Bushen Qiang Jin Zhi Bi Decoction is very effective in the treatment of ankylosing spondylitis（cold dampness obstruction syndrome）,it can not only improve the laboratory indicators of patients,improve the quality of life of patients,but also has no obvious side effects,so it’s worthy to promote in clinical practice.