Clinical Observation On Treatment Of Chronic Obstructive Pulmonary Disease With Acute Exacerbation Of Phlegm-Turbid Obstructing Lung Syndrome By Jiangqi Huatan

Objective:This article attempts to evaluate its efficacy and safety by observing the clinical efficacy of Jiangqi Huatan therapy used to treat AECOPD（Phlegm-turbid Obstructing Lung Syndrome）.Methods:A total of 60 inpatients with AECOPD（Phlegm-turbid Obstructing Lung Syndrome）in Sichuan Hospital of Traditional Chinese Medicine from June 2020 to January2021 were selected and randomly divided into the treatment group（n=30）and the control group（n=30）.The control group was treated with only canonical western medicine.In contrast,the treatment group was treated with Jiangqi Huatan therapy based on the usage of canonical western medicine,with Suzijiangqi decoction and Sanziyangqin decoction.The treatment course of both groups was 10 days.Before and after treatment,TCM syndrome scores,white blood cell,neutrophil percentage,C-reactive protein,arterial blood gas analysis,lung function,CAT score,mMRC score and 6MWD were recorded in 2 groups.After the test,the results were statistically analyzed by SPSS21.0 to evaluate the clinical efficacy of Jiangqi Huatan therapy.At the same time,the safety of the test was evaluated according to the safety indicators.Results:（1）The total effective rate was 96.67%in the experiment group and 86.67%in the control group.The overall curative effect in the experiment group was better than that in the control group（P<0.05）.（2）Compared with the control group,the total score of TCM syndromes in experiment group decreased more significantly（P<0.01）.The improvement of cough,wheezing,sputum,chest sulk and short breath,anorexia,abdominal distension in the experiment group was better than that in the control group（P<0.01）.（3）The treatment group was superior to the control group in the improvement of white blood cell,neutrophil percentage,C-reactive protein,arterial blood gas analysis（PaO₂,PaCO₂）,lung function（FEV₁%pred,FEV₁/FVC）,CAT score,mMRC score and 6-minute walk distance（P<0.05）.（4）Safety evaluation:In addition to the original symptoms,patients in the two groups did not develop new discomfort symptoms during the period of clinical observation.No drug-related adverse reactions were found.The safety indexes of the two groups were not distinctively abnormal.Safety evaluation maintain the level of grade 1.Conclusion:Compared with the routine treatment of western medicine,Jiangqi Huatan therapy combined with routine treatment of western medicine for the treatment of AECOPD（Phlegm-turbid Obstructing Lung Syndrome）can more effectively improve the clinical symptoms,related laboratory indicators and patients’life quality.During the period of clinical observation,there were no obvious adverse reactions and toxic side effects which proved that the Jiangqi Huatan therapy is safe.