Effects Of Jianpi Huatan Recipe On Lipid Metabolism In Obese PCOS-IR Patients With Spleen Deficiency And Phlegm-dampness Syndrome

Objective: To observe the effectiveness of Jianpi Huatan Decoction combined with metformin hydrochloride sustained-release tablets on insulin resistance in obese polycystic ovary syndrome patients(PCOS-IR)with spleen deficiency and phlegm dampness.Taking metformin hydrochloride sustained-release tablets as the control group,the clinical effctiveness and the changes of fat metabolism indexes before and after remedy were compared between the two groups,aiming to explore the influence of Jianpi Huatan Decoction on it and elaborate the effect of TCM on the disease.And by the research,the goal is provid ing rational evidence for the comprehensive remedy of patients of this type and expanding clinical application.Methods:From June 2020 to December 2020,60 outpatients are subsumed from Professor Yang Zhengwang that aged between 20 and40 years old(including 20 and 40 years old)and diagnosed as spleen deficiency and phlegm dampness syndrome.They were split into observation group(Jianpi Huatan Decoction combined with metformin hydrochloride sustained-release tablets)and control group(metformin hydrochloride sustained-release tablets)at random,which are 30 cases in each group.The changes of WC,HC,WHR,blood fat related indexes,adiponectin(ADP),homocysteine(HCY),free fatty acid(FFA),visfatin,score s of TCM and menstruation of the two groups before and after remedy were recorded,counted and analyzed.Results:1.In improving WC,HC and WH R,the observation group was better than the control group(P < 0.05).For WHR,the observation group can cut down WHR,the control group ha d no considerable effect on WHR.2.In terms of the impact on blood fat related in dicators,the observation group contrast with the control group,result was P <0.01;The downward of TC,TG and LDL-C of the two groups was dramatical.HDL-C heightend makedly after remedy,and the effect was better than the observation group3.In the aspect of HCY,ADP,FFA and visf atin,a comparative study of the two grou ps was P < 0.01,both groups can substantially declined HCY after remedy,and the observation group had a superior effectiveness;The observation group of ADP,FFA,visfatin P < 0.05,the control group P> 0.05,the observation group can enhance ADP,reduce FFA and visfatin,but the control group ha d no significant effect on ADP and FFA.4.In terms of menstruation,the comparison between the two groups was P < 0.01.After remedy,the menstruation of the two groups was significantly improved,in contrast wi th the control group,the observation group was superior.5.In the filed of TCM scores,the comparison between the two groups was P < 0.01,after remedy,both groups were ameliorate d and the observation group was more memorabl e.Conclusion:Through the observation of 60 cases of obese PCOS-IR patients with spleen deficiency and phlegm dampness syndrome,it was found that Jianpi Huatan Decoction combined with metformin sustained-release tablets could effectively decrease WC,HC and WHR,improve blood fat related indicators and HCY,ADP,FFA,visfatin,etc.It ha d significant effect on menstrual disorder and TCM syndromes correlatively.And the clinical use was safe and effective,and ha d the value of clinical research and popularization.