| Purpose: The purpose of the research of this subject is to explore the quantifiable laboratory test indicators for strengthening the body resistance and eliminating pathogenic factors,and to guide the objective basis for the selection of the dosage of the anti-pathogenic factor chinese drugs for the treatment of malignant tumors of the digestive system.Method: Between November 2020 to July 2021,the patients admitted to the Oncology Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were randomly divided into regular dose group and high dose group by SPSS24.0 software.The traditional Chinese medicine decoction and anti-pathogenic factor drugs in the regular dose group used conventional doses: 15 g of Smilax glabra(Tufuling),15 g of Scutellaria barbata(Banzhilian),10 g of Dannanxing,and 10 g of zedoary turmeric.The high dose group adopts high-dose traditional Chinese medicine decoction and anti-pathogenic factor drugs: 30 g of Smilax glabra,30 g of Scutellaria barbata,20 g of Dannanxing,and 15 of zedoary turmeric.Statistics of cholinesterase,homocysteine,urea nitrogen test indicators,Symptom and signs score of Chinese Medicine and treatment-related adverse reactions before and after treatment in the two groups were counted.Results: A total of 63 cases were enrolled,this included 32 cases in the high dose group and31 cases in the regular dose group respectively.There was no significant difference between the two groups in age,gender,disease site,cancer stage,and admission PS score(P>0.05).After the treatments,the blood cholinesterase value of the high dose group decreased compared with before treatment,and the comparison between groups decreased compared with the regular dose group.The difference was statistically significant(P<0.05).After treatment,the blood homocysteine and urea nitrogen levels of the high dose group decreased to varying degrees whether they were compared with the group before treatment or between the groups after treatment with the regular dose group,but the difference was not statistically significant(P>0.05).The overall effective rate of the regular dose group was 77.42%,and the overall effective rate of the high dose group was 84.38%.There was no statistically significant difference between the two groups(P>0.05).Among the admitted patients with cholinesterase value <3930 U/L,the effective rate of the regular dose group was 81.82%,and the effective rate of the high dose group was 60.00%.The difference between the two groups was statistically significant(P<0.05).Among the patients admitted to the hospital with cholinesterase value ≥3930 U/L,the effective rate of the regular dose group was 75.00%,and the effective rate of the high dose group was 95.45%.The difference between the two groups was statistically significant(P<0.05).Comparing the two groups after treatment,the overall curative effect was the same,and the difference in symptom scores was not statistically significant.Among the patients with low cholinesterase value admitted to the hospital,the application of conventional doses of antipathogenic factor drugs is better than the use of high-dose anti-pathogenic drugs in relation to the treatment of poor appetite,fatigue,fatigue,abdominal distension and weight loss,and the difference is statistically significant.Significance(P<0.05).In the patients admitted to the hospital with normal or high cholinesterase levels,the application of high-dose anti-pathogenic factor drugs is better than the conventional dose anti-pathogenic factor drugs in the treatment of poor appetite,fatigue,fatigue,abdominal distension and weight loss.It was statistically significant(P<0.05).The treatment effect of the remaining symptoms in the two groups was not related to the cholinesterase value in the hospital,and the difference was not statistically significant(P>0.05).In the regular dose group,1 case(3.23%)had elevated transaminases and 1case(3.23%)had elevated creatinine,and 2 cases(6.25%)in the high dose group had elevated transaminases,and the adverse reactions in each group were grade 1-2,there were no adverse reactions of grade 3 or above.Conclusion: Cholinesterase can be used as a quantifiable test index for vital-qi,clinically,patients with gastrointestinal malignant tumors can be guided based on serum cholinesterase levels.The application of anti-pathogenic factor drugs;whether high-dose anti-pathogenic factor drugs or low-dose anti-pathogenic factor drugs are used,the safety aspect is good,and there is no obvious adverse reaction.In clinical practice,it is necessary to reasonably intervene in different proportions of drugs for the strengthening of body resistance and anti-pathogenic factor drugs base on the prevailing body condition of the patient in terms of adequacy of vital-qi against the pathogenic factors. |
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