Design And Development Of A Mechatronic System For Releasing And Recycling Of Nanomagnetic-Insulin

Diabetes is a serious lifelong illness caused by insulin deficiency,which has become a common public health problem faced by all countries in the world.A fully implantable artificial pancreas system with intraperitoneal glucose sensing and insulin releasing has the advantage of a fast insulin response and no psychological burden to diabetic patients.However,it may require frequent surgical interventions to refill insulin after insulin is used out.By studying the metabolic pathway of insulin,in this study we propose a mechatronic system for releasing and recycling of nanomagnetic-insulin to demonstrate the feasibility of achieving magnetic-assisted insulin recycle and reuse,which may reduce the needs of insulin refill and mitigate hypoglycemia.In the prototype developed in this research,the main functions include the active and accurate release of specific doses of drugs according to the needs of patients,and the corresponding recycle control is initiated when the drugs need to be recycled,so as to achieve the control effect of drug release and recycle.The main work of this topic includes the following four contents:(1)According to the requirements for drug release and recycle,design the corresponding mechanical structure and drive device;(2)Use finite element analysis software to simulate the recycle-driven Archimedes pump of the designed device and optimize its key parameters;(3)Design the core control circuit driver board of the drug release and recycle system,and build the board;(4)D evelop the logic control program of the entire system based on Keil5,and combine the designed mechanical structure and hardware circuit for joint debugging,assembly and experiment.The innovations of this topic include the following two points:(1)Design a drug release system that is actively controlled by the patient and the controller can accurately release the effective dose;(2)The drug recycle electromechanical device is integrated in the drug delivery system,which preliminarily realizes cyclic insulin delivery in artificial pancreas system.