Expression Of Advanced Glycation End Products In A Rat Model Of Polycystic Ovarian Syndrome

Objective: To investigate the expression of advanced glycation end products(AGEs)in a rat model of polycystic ovarian syndrome induced by dehydroepiandrosterone.Methods: The PCOS rat model was established using dehydroepiandrosterone.After confirming that the model rats were set up successfully,serum AGE concentrations were measured using competitive ELISA and the expression of AGE in the ovarian tissues of these rats was detected using immunohistochemistryResults: The serum AGE level in the PCOS group was significantly higher than that in the control group.Furthermore,AGE expression was significantly higher in the PCOS group than in the control group(P < 0.01).Conclusion:AGEs were highly expressed in the rat PCOS model,signifying their importance in the diagnosis and pathogenesis of PCOS.