| Objective: To observe the improvement of Anzhong Decoction on clinical symptoms in patients with PDS of liver-stomach disharmony,as well as its effect on plasma CRH content,evaluate the clinical efficacy of Anzhong Decoction,and explore its mechanism of action.Methods:1.This was a randomized controlled trial,including 72 PDS patients of liver-stomach disharmony syndrome from February 2021 to January 2022 that were divided into Traditional Chinese Medicine(TCM)treatment group(n=36)and Western medicine control group(n=36).There are 36 healthy volunteers from the hospital’s physical examination center were chosen as the healthy control group.Patients in TCM treatment group received oral administration Anzhong Decoction,others in Western medicine control group received Mosapride.The treatment lasts for 4 weeks.2.Collected the general data of the patient’s age,gender,course of disease,et al.Before and after the treatment,patients take the TCM symptom scores scale,self-rating anxiety scale(SAS)and self-rating depression scale(SDS).And we use ELISA method to detect patients’ plasma CRH before and after treatment.Results:1.Comparison of general data: There was no statistically significant difference in age,gender and course of disease between the two groups.2.Comparison of TCM Syndrome efficacy: The total effective rate of TCM treatment group was better than that of the western medicine control group(88.57%vs76.47%,P<0.05).3.Comparison of TCM symptom scores: Comparison within groups: After treatment,the total score of TCM syndromes and each single symptom score in TCM treatment group and Western medicine control group were both significantly lower than those before treatment(P<0.05).Comparison between groups: Before treatment,there was no significant difference in the total scores of TCM syndromes and single symptom score between the two groups(P>0.05).After treatment,the TCM group was superior to the western medicine control group in relieving symptoms of early satiety,fullness of both flanks,seizure or aggravation due to poor mood,belching and upset(P<0.05).There was no statistically significant difference in the two groups in terms of postprandial fullness discomfort,epigastric pain,sighing,nausea and vomiting(P>0.05).4.Comparison of SAS and SDS scores: Comparison within groups: After treatment,the scores of SAS and SDS of TCM treatment group and Western medicine control group were lower than those before treatment(P<0.05).Comparison between groups: Before treatment,there was no significant difference in SAS and SDS scores between the two groups(P>0.05).After treatment,the SAS and SDS scores in TCM treatment group were lower than those in Western medicine control group(P<0.01).5.Comparison of plasma CRH contents: Before treatment,the plasma CRH content of the two groups of patients was higher than that of the healthy control group(P<0.01).After treatment,the plasma CRH of two groups were both decreased(P<0.05),and the plasma CRH of TCM treatment group was lower than that of Western medicine control group(P<0.05).6.Correlation analysis: The total score of TCM syndromes was positively correlated with SAS and SDS scores before and after treatment in patients with liver-stomach discord type PDS(P<0.05),and was positively correlated with plasma CRH content(P<0.05).Plasma CRH content in patients with liver-stomach discord type PDS was positively correlated with SAS and SDS scores(P<0.05).7.There were no adverse reactions in the two groups during the treatment.In conclusion:1.Anzhong Decoction can effectively improve the symptoms in patients with PDS with discordant liver and stomach,and is better than Mosapride,with no obvious adverse reactions.2.Plasma CRH is associated with gastrointestinal discomfort,anxiety and depression in patients with liver-stomach discord type PDS.3.Anzhong decoction in the treatment of liver-stomach discord type PDS may be related to the regulation of plasma CRH level. |
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