| Objective:Through the randomized controlled experiment to observe the clinical efficacy of modified Yinchen Hao decoction combined with blood-prickling cupping therapy in the treatment of spleen-stomach damp-heat acne,evaluate the effectiveness of traditional Chinese medicine combined with blood-prickling cupping therapy for the disease,and discuss its mechanism of action,providing a new therapy idea for the disease.Methods:The trial adopts randomized controlled method principle,90 cases of acne patients who met the inclusion criteria were divided into blood cupping therapy group(Referred to as "external treatment group"),modified Yinchen Hao decoction group(Referred to as "chinese medicine group"),and modified Yinchen Haodecoction combined with blood-prickling cupping therapy group(Referred to as "joint group").According to the ratio of 1:1:1.Each group had 30 cases.External treatment group was treated with pricking blood cupping therapy.once a week as a course of treatment;Prescription of Chinese medicine Group:Herba artemisiae 20 g Gardenia12g Rhizoma atractylodis 9g Magnolia bark 6g Scutellaria baicalensis georgi 10 g Cortex phellodendri 10 g Cortex moutan 15 g Hawthorn 20 g Dried tangerine or orange peel 9g Hedyotis diffusa 20 g System of rhubarb 3g Licorice 6g.The traditional Chinese medicine was prepared by shanxi pharmaceutical pharmacy granules,one dose a day,200 ml boiled water,each morningand evening.One fasting course of treatment: 7 days for a course of treatment,four consecutive courses of treatment;The joint group was based on the chinese medicine group and combined with external therapy,with a course of 7 days.All three groups were treated for 4 courses.Recording The specific values and level changes of skin lesion score,syndrome score and quality of life score before treatment,2 weeks after treatment and 4 weeks after treatment.Meanwhile analysis the clinical efficacy of the three groups.The skin lesions,syndromes and quality of life improvement of the patients were compared within each group and in pairs among the three groups.SPSS25.0 statistical software was used for statistical analysis.Results:1.Skin lesions objective symptom score comparison:After treatment,the skin lesion score of the three groups decreased significantly compared with that before treatment.There were statistically significant differences between the three groups before treatment and 2 weeks after treatment,before treatment and 4 weeks after treatment,2 weeks after treatment and 4 weeks after treatment(P<0.05);After 2 weeks of treatment,pairwise comparisons between the three groups showed statistically significant differences(P<0.05);after 4 weeks of treatment,the differences were statistically significant(P<0.05)between the joint group and the external treatment group,and between the joint group and the chinese medicine group.And there was no significant difference(P>0.05)between the external treatment group and the chinese medicine group.After 2 weeks of treatment,there were statistically significant differences in papules,pustules,skin color,inflammatory erythema or pigmentation and grease between the joint group and the external treatment group(P<0.05),and there was no significant difference in cysts or nodules(P>0.05).There were statistically significant differences in papules,pustules,skin color and inflammatory erythema or pigmentation between the joint group and the chinese medicine group(P<0.05),and there was no significant difference in cysts or nodules and grease(P>0.05).There were statistically significant differences in papules,pustules,and grease between the external treatment group and the chinese medicine group(P<0.05),and there was no significant difference in cysts or nodules,skin color and inflammatory erythema or pigmentation(P>0.05).After 4 weeks of treatment,there were statistically significant differences in papules,pustules,skin color,inflammatory erythema or pigmentation and grease between the joint group and the external treatment group(P<0.05),and there was no significant difference in cysts or nodules(P>0.05).There were statistically significant differences in papules,pustules,skin color and inflammatory erythema or pigmentation between the joint group and the chinese medicine group(P<0.05),and there was no significant difference in cysts or nodules and grease(P>0.05).There were statistically significant differences in papules,pustules,skin color,inflammatory erythema or pigmentation and grease between the external treatment group and the chinese medicine group(P<0.05),and there was no significant difference in cysts or nodules(P>0.05).2.Chinese medicine subjective symptom score comparison:After treatment,the syndrome scores of the joint group,the external treatment group and the chinese medicine group all decreased significantly compared with those before treatment.In the joint group,the differences were statistically significant between before treatment and 2 weeks after treatment,between before treatment and 4 weeks after treatment,and between 2 weeks after treatment and 4 weeks after treatment(P<0.05).In the external treatment group,there was no significant difference between before treatment and 2 weeks after treatment,before treatment and 4 weeks after treatment,and 2weeks after treatment and 4 weeks after treatment(P>0.05).In the chinese medicine group,there were statistically significant differences between before and after treatment for 2 weeks,before and after treatment for 4 weeks,and between 2 weeks and 4 weeks(P<0.05).After 2 weeks and 4 weeks of treatment,there were statistically significant differences between the joint group and the external treatment group,and the external treatment group and the chinese medicine group(P<0.05).There was no significant difference between the joint group and the chinese medicine group(P>0.05).3.Quality of Life score comparison:After treatment,the scores of quality of life in the three groups decreased significantly compared with before treatment,and the differences were statistically significant in the three groups before and after treatment(P<0.05);Comparison between the three groups after treatment,there were statistically significant(P<0.05)between the joint group and the external treatment group,and between the joint group and the chinese medicine group;While the differences between the external treatment group and the chinese medicine group were not statistically significant(P<0.05).4.Clinical efficacy analysis:The total effective rate was 93.33% in joint group,86.67% in external treatment group and 80.00% in chinese medicine group.The differences were statistically significant between the joint group and the external treatment group,the joint group and the chinese medicine group(P<0.05),while there was no statistically significant difference between the external treatment group and the chinese medicine group(P>0.05).The results showed that the joint group had better overall curative effect than the external treatment group and chinese medicine group.Conclusion:1.Modified Yinchen Hao decoction combined with blood-prickling cupping therapy and modified Yinchen Hao decoction combined can effectively improve patients’ skin lesion score,syndrome score and quality of life score.Blood-prickling cupping therapy can effectively improve the skin lesion score and quality of life score,but the improvement of syndrome score was not obvious.The clinical symptoms of the patients were significantly relieved in all three groups.2.Compared with simple oral chinese medicine and external treatment,modified Yinchen Hao decoction combined with blood-prickling cupping therapy has a quick effect in the treatment of spleen-stomach damp-heat acne,meanwhile the curative effect is more significant and the comprehensive effective rate is higher.It is worthy of clinical application and promotion. |
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