| Objective: To observe the clinical efficacy and safety of Qingre Dingchuan Decoction in the treatment of acute exacerbation of bronchial asthma of phlegm-heat in the lung.Methods: From November 2021 to November 2022,60 patients with acute episode of bronchial asthma of phlegm-heat accumulation in lung type were randomly divided into observation group(30 cases)and control group(30cases).The control group was given budesonide formoterol powder inhalation(Astra Zeneca Symbicort Turburet)and montelukast sodium tablets(Jiangsu Wangao),and the observation group was given Qingre Dingchuan Decoction on the basis of the treatment,with a total course of 2 weeks.Asthma control test was performed in both groups before and after treatment(ACT),TCM Symptom Score Scale,Pulmonary Function(FEV 1,PEF),forced expiratory flow rate(MEF25,MEF50,MEF75,MMEF75/25),exhaled nitric oxide(Fe NO),peripheral blood C-reactive protein(CRP)and eosinophil(EOS)count,SPSS26.0 software was used for data processing,the efficacy of the two groups was compared,the ECG,liver and renal function and other indicators before and after treatment were observed,and the adverse events occurred during treatment were counted to evaluate the safety.Results:1.Clinical curative effect: The total effective rate of the observation group was 96.67%,and that of the control group was 80.00%,the difference was significant(P <0.05).2.TCM syndrome score: After treatment,the total score of TCM syndrome in the observation group and the control group was 12.88 ± 4.98 and 17.29± 4.25 respectively,and the improvement in the observation group was more significant(P <0.05).The two groups were compared before and after treatment of each single syndrome integral,the two groups have achieved significant improvement,there are significant differences(P <0.05);There was significant difference between the two groups in relieving the main symptoms such as wheezing,wheezing,cough and the secondary symptoms such as expectoration,dry mouth,thirst and liking cold drink(P <0.05).There was no significant difference in relieving cough and shortness of breath between the two groups after treatment(P> 0.05).3.Asthma control test(ACT)score:The ACT scores of the two groups were significantly improved after treatment,and the difference was significant(P <0.05).After treatment,the score of the observation group was significantly higher than that of the control group,with statistical significance(P <0.05)4.The functional indicators of the large airway:FEV 1 of the two groups improved significantly after treatment(P <0.05),but PEF of the two groups had no significant difference.There was significant difference in FEV 1between the two groups(P <0.05).There was no significant difference in improving PEF between the two groups(P> 0.05).5.The indexes of small airway function: MEF50 and MEF75 were significantly improved in both groups after treatment(P> 0.05),but MEF25 and MMEF75/25 had no significant change in both groups(P> 0.05).After treatment,the improvement of MEF50 in the observation group was significantly higher than that in the control group(P <0.05),but there was no significant difference in the values of MEF25,MEF75 and MMEF75/25 between the two groups(P> 0.05).6.Fractional exhaled nitricoxide(Fe NO):After treatment,Fe NO 50,Fe NO200 and Ca NO in both groups decreased significantly(P <0.05).After treatment,the value of observation group decreased slightly more than that of control group,but there was no significant difference between the two groups(P>0.05).7.Peripheral blood eosinophil(EOS)count:After treatment,the two groups were significantly reduced than before(P <0.05);Compared with the improvement level of EOS count between the two groups,the observation group showed more obvious decrease in EOS count after treatment,with significant difference(P <0.05).8.Peripheral blood C-reactive protein(CRP)count:There were significant differences in the counts before and after treatment between the two groups(P <0.05).CRP count improvement level between the two groups,the observation group after treatment was significantly better than the control group(P<0.05).9.No adverse events occurred in both groups after the study.Conclusion: Qingre Dingchuan Decoction combined with western medicine can effectively relieve the main symptoms of asthma,such as wheezing,wheezing,cough,and the secondary symptoms of expectoration,dry mouth and cold drink.improve FEV 1 and MEF 50% and airway ventilation function;reduce the levels of inflammatory factors such as EOS and CRP,thereby relieving the inflammatory reaction and reducing the level of airway hyperreactivity.This study shows that Qingre Dingchuan Decoction combined with conventional western medicine treatment can relieve the clinical symptoms of patients with acute attack of bronchial asthma of phlegm-heat accumulation in the lung in a short period of time,and achieve significant clinical efficacy,without adverse events,good safety,worthy of popularization and application. |
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