| Objective: Through the clinical observation of gout prescription in the treatment of patients with humid heat stasis chronic gouty arthritis,the therapeutic effect and safety of this prescription were analyzed,which provided scientific basis for the clinical application of traditional Chinese medicine in the treatment of chronic gouty arthritis.Methods: This study selected 71 outpatients and inpatients from Shandong University of Traditional Chinese Medicine Affiliated Hospital according to the inclusion and exclusion criteria.The two groups were randomized by random number table.The test group was 36 cases and thecontrol group was35 cases.Control group received basic treatment and Febuxostat while the experimental group received gout prescription inaddition to the basic treatment received by the control group.The course of treatment was 12 weeks.The indices including the uric acid,blood sedimentation rate,Creactive protein,Chinese medicine syndrome integral,and musculoskeletal ultrasound(synovial hyperplasia,blood flow signal,joint effusion and bone erosion,etc)before and after treatment were recorded respectively.The indices of safety such as blood routine,liver and kidney function were monitored,and the indicesincluding gout relapse rate within three months after the end of the treatment in the two groups were recorded.IBM SPSS26.0 software was used to analyze the dataandevaluate the clinical efficacy,safety,and gout relapse situation.Results:1.Comparison of general data before treatment between the two groups: There was no statistically significant difference in gender,age and course between the two groups,and comparability(P>0.05).2.Comparison of curative effect of traditional Chinese medicine symptomtotality after treatment between the two groups: The effective rateofth test group was 88.88%,and the effective rate of the controlgroupwas68.57%.The curative effect of the test group was better than thatof the control group(P<0.05).3.With regard to the Chinese medicinesyndrome integral before and after treatment in the two groups: Therewas no significant difference in the total score and single item score of Chinese medicine syndrome before treatment in the two groups,andthey were comparable(P>0.05).The total score and single item scoreof Chinese medicine syndrome(joint pain,joint swelling)were reduced in both groups,and the experimental group was better than thecontrol group(P<0.05).4.Before treatment,there was no significant difference in uric acid between the two groups(P>0.05),and both groups had a decrease in uricacid levels,with the experimental group better than the control group(P<0.05).There was no statistical difference in red blood cell sedimentation and Creactive protein before treatment between the two groups(P>0.05),and there was a decrease in both red blood cell sedimentation and C-reactive protein,and the two groups had similar effectiveness in improving red blood cell sedimentation and C-reactive protein indicators(P>0.05).5.Before treatment,there was no statistical difference in synovial hyperplasia,blood flow signal,joint effusion and bone erosion between the twogroups(P>0.05),and both groups had improved in synovial hyperplasia,blood flow signal and joint effusion,with the experimental group better than the control group(P<0.05);There was no obvious improvement in boneerosion in both groups(P>0.05).6.The recurrence rate of gout after treatment between two groups were 8.33%in the experimental group and 14.28% in the control group.There was no significant difference between the two groups(P>0.05).Conclusion:The combined treatment of painkiller with fenbufen for patients with chronic gouty arthritis with moist-heat stasis type is superior tosingle use of fenbufen in terms of improvement of TCM clinical syndrome(joint pain,joint swelling),decreasing uric acid,musculoskeletal ultrasound(synovial hyperplasia,blood flow signal,jointeffusion),and has higher drug safety,worth being clinicallypromoted. |
