Correlation Analysis Of High Macular Reflex Points And Clinical Features In Patients With Branch Retinal Vein Occlusion

Part 1: Correlation between hyper-reflection points in OCT of retinal branch vein occlusion and blood lipids and inflammatory indexes in peripheral bloodObjective: To explore the correlation between the number of hyperreflective foci(HF)in each layer of retina in OCT with branch retinal vein occlusion(BRVO)and the level of blood lipids and inflammatory indicators in peripheral bloodMethods: In the study,a cross-sectional clinic was conducted,including 63 patients(63 eyes)diagnosed with BRVO in our eye clinic from July 2019 to August 2022.Peripheral venous blood was taken from the laboratory of our hospital within three days after eye examination,and the neutrophil count,neutrophil percentage,lymphocyte count,absolute number of monocytes,C-reactive protein(CRP),total cholesterol,triglyceride,high-density lipoprotein cholesterol(HDL),low-density lipoprotein cholesterol(LDL)and lipoprotein A were automatically detected.Calculate neutrophil count/lymphocyte count(NLR)The optical coherence tomography(OCT)equipment was used to count HF.According to the different distribution of HF in the retina,HF was divided into the inner layer of the retina,the outer layer of the retina,and the total HF of the retina.Pearson or Spearman correlation was used to analyze the correlation between HF count,blood lipid level and inflammatory index in BRVO patients.Results: The HF count in the outer retina of BRVO patients was positively correlated with the percentage of neutrophils,total cholesterol,low density lipoprotein and the absolute number of monocytes(r=0.479,0.387,0.511,P=0.000,0.002,0.000);The total retinal HF count was positively correlated with the absolute number of monocytes(r=0.256,P=0.043).There was no correlation between HF count and neutrophil count,lymphocyte count,CRP,high-density lipoprotein,lipoprotein a,NLR.(P>0.05)Conclusion: The HF count on OCT of BRVO is correlated with blood lipid and inflammation index.Part 2: Analysis of the correlation between the high reflection point in OCT of retinal branch vein occlusion and the efficacy of intravitreal injection of Ranibizumab and the structure of macular areaObjective: To explore the relationship between the number of hyperreflective foci(HF)in the outer retina of OCT with branch retinal vein occlusion(BRVO)and the efficacy of intravitreal injection of Ranibizumab and the structure of macular areaMethods: Retrospective cohort study.51 cases(51 eyes)of BRVO patients who were treated in the ophthalmology clinic of our hospital from July 2019 to June 2022 and who were injected with intravitreal anti-VEGF drugs by experienced doctors were included in this study.According to the integrity of ELM on OCT,it is divided into two groups: group A is the complete ELM group,with a total of 22 cases;group B is the incomplete ELM group,with a total of 29 cases.All patients were treated with intravitreal injection of antiVEGF(3+PRN).The changes of best corrected visual acuity(BCVA),average retinal thickness(ART)and central macular retinal thickness(CMT)of two groups of patients with intravitreal injection of leizhumab were compared before and two weeks after operation,one month after operation,two months after operation and three months after operation,and the differences between the two groups were compared.To analyze the correlation between HF in the outer retina and BCVA,ART and CMT 2 weeks,1 month,2 months and 3 months after operation,and analyze the indexes correlated with the last follow-up BCVA.Results: In the ELM incomplete group,the number of HF and CMT in the outer layer of retina were higher than those in the ELM complete group,and the BCVA was worse;After the operation of anti-VEGF drugs,the number of HF in the outer retina of the two groups decreased,BCVA improved,CMT and ART became thinner,but CMT increased slightly and BCVA decreased in 3 months after the operation.Correlation analysis results: In the group with incomplete ELM,the number of HF in the outer layer of retina was correlated with BCVA(all P<0.05);There was a correlation between BCVA and HF in the outer layer of retina at 3 months after operation(all P<0.05).Conclusion: Anti-VEGF drugs are effective in the treatment of macular edema secondary to BRVO.There is a correlation between HF in the outer layer of retina and the degree of ELM damage and visual prognosis.