Effect Of Different Doses Of Bone Cement On PVP Treatment Of Lumbar Single Level OVCF With The Same Degree Of Compression

Objective: To compare the clinical efficacy of different dosages of bone cement in the treatment of single level lumbar vertebra osteoporotic vertebral compression fracture(OVCF)with the same degree of compression by percutaneous puncture vertebroplasty(PVP),evaluate the correlation between different dosages of bone cement and clinical efficacy,and provide evidence-based medical evidence for the treatment of OVCF.Methods:Retrospective analysis was performed on patients with osteoporotic vertebral fractures of single level lumbar vertebra with the same degree of compression admitted to the Spinal Department of the First Affiliated Hospital of Guangxi University of Chinese Medicine from January2019 to December 2021.According to the inclusion and exclusion criteria,A total of 98 patients eligible for inclusion were selected and divided into three groups according to different bone cement injection amounts,including 36 patients in group A.The treatment dosage of bone cement was 3.0-4.9ml;32patients in group B were treated with 5.0-6.9ml bone cement.30 patients in group C were treated with more than 7ml bone cement.Preoperative vertebral height,cobb Angle of injured vertebra,visual analogue scale(VAS)and The Oswestry Disability Index(ODI)of the three groups were recorded,respectively.By comparing the changes of the above four outcome indexes and the leakage rate of bone cement after surgery,the clinical efficacy and advantages of different dosages of bone cement in PVP treatment of lumbar single level OVCF with the same degree of compression were discussed.Results: A total of 98 patients were included in this study,including 36 patients in group A,including 10 males and 26 females.There were 32 patients in group B,including 3 males and 29 females.There were 30 patients in group C,including 5 males and 25 females.There were no significant differences in age,sex,body mass index,fracture segment,preoperative VAS score and preoperative ODI index among the three groups(P > 0.05).Postoperative VAS score and ODI score of the three groups were significantly decreased compared with those before surgery,with statistical significance(P< 0.05),but there was no statistical significance in VAS score and ODI score of the three groups at 1 week,6 months and 1 year after surgery(P > 0.05).The postoperative vertebral height of the three groups was significantly higher than that before surgery,the difference was statistically significant(P < 0.05),but there was no statistically significant difference between the three groups(P > 0.05).The cobb Angle of the injured vertebra in the three groups after surgery was significantly smaller than that before surgery,the difference was statistically significant(P < 0.05),but there was no statistically significant difference between the three groups(P > 0.05).The comparison of postoperative bone cement leakage rate among the three groups showed that there was no statistical significance in the bone cement leakage rate between group A and group B,but there was statistical significance in the bone cement leakage rate between group A and group B and group C(P < 0.05).Conclusion(s):In PVP treatment of lumbar single level OVCF with the same compression degree,patients treated with different dosages of bone cement had better clinical efficacy,but patients treated with medium and low dosages of bone cement(3.0ml to 6.9ml)had lower risk of bone cement leakage than those treated with high dosages of bone cement(over 7ml).There is less risk of complications that may occur after surgery.