Effect Of Qinggan Mingshi Decoction On Non-proliferative Diabetic Retinopathy And 25-(OH)D

Objectives To observe the clinical efficacy of Qinggan Mingshi Decoction in treating patients with mild and moderate non-proliferative diabetic retinopathy(NPDR)who have liver depression yin deficiency and blood-heat bleeding syndrome,to provide more options for treatment of NPDR.Methods 1 92 patients with mild to moderate NPDR(liver depression Yin deficiency and blood-heat bleeding syndrome)were randomly divided into experimental group 46 and control group 46 according to the order of consultation.2 Both groups received basic treatment,the control group was given calcium dobesilate capsules on the basis of basic treatment,experimental group was given Qinggan Mingshi Decoction on the basis of control group,both groups took the drug for 12 weeks.3 The changes of blood glucose(FPG,Hb A1c),blood lipids(TC,TG,LDL-C,HDL-C),visual acuity,TCM syndrome integral,25-(OH)D,and the pathological changes of eyeground(the number of microangiomas,hemorrhagic spots and exudates)were recorded before and after treatment in both groups.SPSS 21.0 statistical software was applied to organize and analyze the data.Results 1 There were no statistically significant differences in gender,age,disease duration and degree of retinopathy between the two groups before treatment(P > 0.05),which were comparable.2 TCM syndrome scores and efficacy: the TCM syndrome scores of both groups decreased after treatment compared with before treatment,and the differences were statistically significant(P < 0.05),the experimental group was better than the control group after treatment(P < 0.05).The total effective rate of the patients after treatment was 84.1% in the experimental group and 65.9% in the control group,and the experimental group was higher than the control group(P < 0.05).3 25-(OH)D: The 25-(OH)D levels increased in both groups treatment(P < 0.05),and the experimental group was better than the control group(P < 0.05).4 Pathological changes of eyeground condition: the number of microangiomas,hemorrhagic spots and exudates decreased in both groups treatment(P < 0.05),and the experimental group was better than the control group(P < 0.05);compared with the fundus efficacy after treatment,the apparent efficiency rate was 79.5% in the experimental group and 59.1% in the control group,and the experimental group was higher than the control group(P < 0.05).5 Visual acuity: the visual acuity increased in both groups treatment(P < 0.05),and the experimental group was better than the control group(P < 0.05);the total effective rate of visual acuity after treatment,the experimental group was 84.1% and the control group was 68.2%,the experimental group was higher than the control group(P < 0.05).6 Blood glucose: FPG and Hb A1 c levels dropped in both groups treatment(P < 0.05),with the experimental group was better than the control group(P < 0.05).7 Blood lipid: TC,TG,LDL-C,and HDL-C levels improved in both groups treatment(P < 0.05),with the experimental group was better than the control group(P < 0.05).8 Safety: There were no significant adverse reactions in both groups after treatment,and no significant abnormalities were found in vital signs,blood,urine,stool routine,liver and kidney functions,and electrocardiogram,etc.The safety of patients was good.Conclusions Qinggan Mingshi Decoction combined with calcium dobesilate capsules can improve the TCM syndrome,pathological changes of eyeground(the number of microangiomas,hemorrhagic spots and exudates),visual acuity,25-(OH)D,blood glucose and blood lipid in the treatment of patients with mild to moderate NPDR liver depression yin deficiency and blood-heat bleeding syndrome,and the efficacy is better than that of calcium dobesilate capsules alone,without the occurrence of adverse reactions.Figure0;Table13;Reference109...