Analysis Of Curative Effect Of Malong Dingchuan Mixture On Children Bronchial Asthma During Acute Attack(Mixed With Deficiencyb And Fullness)

Objective:This topic is to explore the clinical effect of Malong Dingchuan mixture in the treatment of children bronchial asthma in the acute attack period(mixed type).Methods:Sixty children with bronchial asthma diagnosed as acute attack stage(mixed with dummy and solid)were randomly assigned to the pediatric clinic of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from November 2021 to December 2022.The control group(n=20)was given budesonide suspension combined with Boliconil atomizing solution.The experimental group(n=40)was treated with Malong Dingchuan mixture for 2 weeks.The observation results of major and minor symptoms before and after treatment were compared and scored between the two groups,as well as the differences in vanishing time of wheezed sound,childhood Asthma Control Questionnaire(C-ACT)and lung function(FEVi/FVC).Results:1.60 children participated in the clinical study,among which 1 child in the experimental group withdrew from the experiment due to poor compliance and failure to take medicine on time,and 1 child was treated in an external hospital with other drugs,which affected the efficacy evaluation and withdrew from the experiment.In the control group,1 child was suspected to be allergic to therapeutic drugs and withdrew from the experiment;in the control group,1 child was treated in another hospital and added other drugs,which affected the evaluation of efficacy and withdrew from the experiment.A total of 56 children were observed in the experimental group(38 cases)and the control group(18 cases).2.Analysis of clinical efficacy:The total effective rate of Malong Dingchuan mixture group was 84.2%,which was significantly higher than that of nebulized inhalation western medicine group,which was 83.3%and differences were statistically significant(P<0.05).3.TCM syndrome scores:The scores of primary and secondary symptoms of TCM in both groups were lower than before treatment(P<0.05).The scores of Malong Dingchuan mixture group after treatment were lower than those of nebulizing inhalation western pharmacy group,and differences were statistically significant(P<0.05),indicating that the curative effect of Malong Dingchuan mixture group after treatment was better than that of nebulizing inhalation western medicine group.4.Childhood asthma Control Questionnaire(C-ACT):The C-ACT score of the two groups was significantly increased after treatment(P<0.05).The CACT score of Malong Dingchuan mixture group after treatment was lower than that of atomized inhalation western pharmacy group,and differences were statistically significant(P<0.05).5.Disappearance time of wheezing sound:The disappearance time of wheezing sound in the experimental group was shorter than that in the control group after treatment,and the difference was statistically significant(P<0.05),indicating that the treatment effect of Malong Dingchuan mixture group was better than that of nebulized western medicine group.6.Comparative lung function:After the treatment,the pulmonary function(FEV1/FVC)of the two groups of children over 8 years old(15 cases)was examined,and the level of lung function was improved compared with that before treatment(P<0.05).The improvement of Malong Dingchuan mixture group was better than that of nebulizer inhalation group,and the difference was statistically significant(P<0.05).7.Safety assessment:In this study,vital signs were stable before and after treatment,vital signs were stable before and after treatment,and there were no abnormalities in liver,kidney and electrocardiogram.During treatment,one child in the control group developed oropharyngeal discomfort and hoarseness.Considering the possible side effects of aerosol inhalation of budesonide,the symptoms were relieved after treatment.There were no other adverse reactions.Conclusion:1.Malong Dingchuan mixture was used to treat children with bronchial asthma at acute attack stage(mixed with deficiency and accumulation),which had outstanding advantages in controlling and improving asthma-related symptoms,TCM syndromes and improving the total effective rate.2.Malong Dingchuan mixture is more effective than Western medicine in improving pulmonary function scores of children with bronchial asthma in acute attack stage(mixed with deficiency and solid).3.In terms of shortening the disappearance time of wheezing and reducing C-ACT score in children with acute attack of bronchial asthma(mixed with dummy and solid),Malong Dinasthma mixture has more advantages than western medicine treatment with atomized inhalation.