Clinical Efficacy Study On The Treatment Of Cough Variant Asthma In Children With Baiheqingjin Granule And Analysis Of The Pathogenic Factors

Objective: To evaluate the clinical efficacy and safety of Baihe Qingjin Granules in the treatment of Cough Variant Asthma(Liver and lung irritation)in children;and investigate the possible factors influencing the development of CVA in children.Methods:In the first part of the clinical study,100 children were included in the study and were divided into a test group and a control group by randomisation.The test group was given Baixha Qingjin granules and the control group was given nebulised inhalation budesonide aerosol for 4 weeks.The main symptoms,secondary symptoms,recurrence rate and safety were compared between the two groups.The second part of the analysis of morbidity factors was to collect information on gender,age,personal and family history and living environment of 60 children with CVA and 60 healthy children attending our hospital,and to analyse the factors that may influence the development of CVA in children using logistic regression models in order to provide a reference for the prevention,family care and treatment of this condition.Results:Part I,1.Baseline comparability: A total of 107 cases meeting the criteria were included in this study.For reasons of medication compliance and distance,the last 100 children completed clinical observation,60 in the test group and 40 in the control group.The general data(age,gender and duration of illness at the time of consultation)of the children in the two groups were compared and the differences were not statistically significant(>0.05)and were comparable.The differences were not statistically significant(>0.05)and were comparable.2.Clinical efficacy: The total effective rate of treatment in the test group was 95%,which was higher than that of the control group,which was 85%,and the difference was statistically significant(<0.05).The difference was statistically significant(<0.05),which indicated that the treatment of both the experimental Baixiao Qingjin granules and the control group of budesonide aerosol was effective.3.Relapse rate:The relapse rate of the experimental group was lower than that of the control group at the follow-up 3 months after the end of treatment.Part II,1.-General information: A total of 60 children with CVA were included in this study as the observation group and 60 healthy children as the control group,and the gender and age of the children in the two groups were compared,and the results showed that the differences between the two groups in terms of gender and age were not statistically different(P < 0.05)and were comparable.2.Univariate analysis: After conducting a univariate analysis of each morbidity-related factor After univariate analysis,the results showed that seven factors,namely history of atopic dermatitis,history of allergic rhinitis,history of recurrent respiratory infections,history of adenoid hypertrophy,history of chronic cough/bronchial asthma in first and second degree family members,atopic body condition in first and second degree family members,and history of smoke exposure,were associated with the development of cough variant asthma in children.3.Multi-factor analysis: After univariate analysis to eliminate irrelevant factors,the remaining The results were obtained after logistic regression analysis of the remaining 7 factors associated with the onset of cough variant asthma,including history of recurrent respiratory infections,first-and second-degree family members with chronic cough/bronchial asthma,and history of smoke exposure.History of recurrent respiratory infections,history of chronic cough/bronchial asthma in first and second-degree family members,and history of smoke exposure were associated with the development of CVA in children.Conclusion:1.The treatment of CVA in children with Baixha Qingjin Granules is superior to glucocorticoid inhalation alone in terms of overall efficiency.Baixha Qingjin Granules can significantly improve the symptoms of cough,reduce the degree of cough,shorten the duration of cough,and at the same time reduce other related symptoms,such as sputum production and dry and itchy pharynx,which are worthy of further promotion in clinical treatment.2.The factors associated with the development of cough variant asthma in children are a history of recurrent respiratory infections,a history of chronic cough/chronic cough in one or two family members,and a history of smoke exposure,the development of which is the result of a combination of factors.