| Research purpose: Based on the theory of Chinese medicine master Zhang Zhen’s Shutiao Qi mechanism,this subject cooperates with the use of Jiawei Shutiao Decoction on the basis of conventional western medicine treatment for patients with liver-qi stagnation type hypertension and anxiety.By observing and comparing the levels of blood pressure,renin,aldosterone,plasma cortisol,angiotensin II before and after treatment,as well as the Hamilton Anxiety Scale(HAMA),Self-rating Anxiety Scale(SAS)TCM syndrome score and quality of life score were used to evaluate the clinical effect of Jiawei Shutiao Decoction on patients with hypertension and anxiety.Research methods: A total of 72 patients with liver-qi stagnation hypertension complicated with anxiety who meet the needs of the randomized study in two groups,half patients in each group and the treatment course was unified for 3 months.The control group was treated with conventional antihypertensive agents and combined with oral flupentazine and melitracene tablets;Based on the treatment plan of the control group,the experimental group was supplemented with a "Jiawei Shutiao Decoction".The levels of blood pressure,renin,aldosterone,plasma cortisol and angiotensin II before and after treatment were observed and compared,as well as the Hamilton Anxiety Scale(HAMA),Self-Rating Anxiety Scale(SAS),TCM syndrome score and Du Pont’s hypertension quality of life score.Research results:1.Comparison of blood pressure level: The systolic and diastolic blood pressure of the two groups decreased significantly after treatment(P<0.01),and the degree of decline in the treatment group was significantly higher than that in the control groups(P<0.01).2.Comparison of four indicators of hypertension: After treatment,renin,angiotensin II and plasma cortisol in the two groups were significantly improved(P<0.01),and the reduction of renin and angiotensin II in the treatment group was better significantly than in the other group(P<0.01).But after treatment,there was no statistically significant difference in plasma cortisol between the two groups(P>0.05).There was no significant reduction in aldosterone in both groups(P>0.05).3.Comparison of anti-anxiety disorder effects: The score of the Hamilton Anxiety Scale(HAMA)and Self-Rating Anxiety Scale(SAS)of patients was decreased in the two groups after treatment(P<0.01).The HAMA score in the treatment group was significantly lower than that in the control group(P<0.01),and the SAS score in the treatment group was lower than that in the control group after treatment(P<0.05).4.Comparison of clinical curative effect of traditional Chinese medicine: the total effective rate of the control group is 70.59%,and the total effective rate of treatment group is88.24%.The total effective rate of the treatment group is higher than that of the control group(P<0.05).5.Comparison of single integral of TCM syndrome: In the treatment group,the scores of dizziness,headache,restlessness,insomnia,chest tightness and sighing were very significantly improved before and after treatment(P<0.01),the scores of abdominal distension and constipation were significantly improved before and after treatment(P<0.05).In the control group,the scores of dizziness,headache,restlessness,chest tightness and sighing were very significantly improved before and after treatment(P<0.01),the scores of insomnia,abdominal distension and constipation were significantly improved before and after treatment(P<0.05).After treatment,the score reduction of dizziness and sighing in the treatment group was significantly better than that in the control group(P<0.01),and the score reduction of headache,restlessness,insomnia,chest tightness in the treatment group was better than that in the control group(P<0.05).After the treatment,there is no difference in the scores of abdominal distension and constipation between the two groups(P>0.05).6.Comparison of Du Pont’s hypertension quality of life score: the quality of life score of patients in the two groups improved after treatment(P<0.01),the score of the treatment group is higher than that of the other group(P<0.05).Conclusion:1.Jiawei Shutiao decoction can better improve the clinical symptoms of patients with liver-qi stagnation type hypertension and anxiety.2.Compared with the simple Western medicine group,the combined use of Jiawei Shutiao Tang can further reduce the plasma renin and angiotensin II of patients in orthostatic position,which may be related to the regulation of RASS and effectively reduce blood pressure.3.Jiawei Shutiao decoction can effectively improve the anxiety of patients and improve their quality of life.4.Jiawei Shutiao decoction is safe and reliable without obvious adverse reactions in the treatment of liver-qi stagnation type hypertension with anxiety. |
