Association Between Preoperative Immune Cell Classification Count In Peripheral Blood And Postoperative Lymph Node Metastasis And Pathological Stage In Patients With Colorectal Cancer

Objective(s):Explore the relationship between preoperative immune cell classification count in peripheral blood and postoperative lymph node metastasis and pathological stage in patients with colorectal cancer.Methods:161 patients undergoing colorectal cancer resection from September 2020 to the first general department of Yunnan First People’s Hospital from December 2022 were selected for retrospective study.93(58%)male patients and 68 female patients(42%)were selected,with an average age of 61.84 years old(22-87 years old).The preoperative blood cell count,neutrophil count,lymphocyte count,platelet count,and hemoglobin count were collected;postoperative pathological examination information was collected to make lymph node metastasis rate and lymph node metastasis calculated;the cases were divided by mean NLR and PLR into high NLR,low NLR,high PLR and low PLR respectively.The association between preoperative NLR,PLR and clinicopathology were analyzed;univariate analysis of the factors associated with lymph node metastasis.Results:1.The high NLR group was associated with neurovascular invasion,and the high PLR group was associated with the maximum tumor diameter.There were no significant differences between preoperative NLR and PLR and gender,age,BMI,diabetes,hypertension,smoking,alcohol consumption,tumor location,gross tumor morphology,tissue type,infiltration depth,lymph node stage,TNM stage,and differentiation;2.Gross morphology,infiltration depth,nerve vascular invasion,and maximum diameter of tumor were significantly associated with lymph node metastasis.Factors such as age,gender,BMI,diabetes,hypertension,smoking and drinking,tumor location,tissue type,differentiation,NLR,and PLR were not significantly associated with lymph node metastasis.Conclusion(s):1.The white blood cell count can be used as an assist in predicting the degree of lymph node metastasis in patients with colorectal cancer.2.NLR and PLR can reflect the immune function of the body,but their value cannot indicate the early or late clinical stage of tumor.