Literature Study On The Application Law Of Traditional Chinese Medicine And Acupuncture And Moxibustion In The Treatment Of Perimenopausal Syndrome Based On Data Mining

Objective: Through statistics of CNKI on the clinical research literature of Traditional Chinese medicine(TCM)and acupuncture and moxibustion related to the treatment of perimenopausal syndrome from 2012 to 2021,was conducted to excavate its application rules of syndrome differentiation,medication and acupoint selection in order to provide better literature data support and reference for the clinical treatment of perimenopausal syndromeMethods : The Chinese Journal Database China national knowledge infrastructure(CNKI)was used to collect the related clinical research literature and acupuncture from 2012 to 2021.Based on the inclusion and exclusion criteria,screen the last included documents,extract the information in the documents and the database is established.After the data is standardized and processed,it is divided into two parts: traditional Chinese medicine and acupoints for analysis.The documents are analysed by using Excel for metrology,and IBM MODELER is used for correlation analysis between drugs and syndrome types,between drugs and drugs,between acupoints and syndrome types,and between acupoints and acupoints.IBM is used to cluster high-frequency drugs and acupoints,so as to summarize the rules of syndrome differentiation,medication and acupoint selection in the treatment of menopausal syndrome with traditional Chinese medicine.Result:1.Medicine: Analysis of syndrome differentiation: in 368 clinical documents,there are 20 syndromes after standardization.The highest frequency are liver and kidney yin deficiency syndrome 27.45%.following are kidney yin deficiency syndromes 22.55%,kidney deficiency with liver depression syndrome16.30%,heart and kidney deficiency syndrome 7.88%,yin deficiency and fire hyperactivity syndrome 7.88%,kidney yin and yang deficiency syndromes 7.34%,liver qi stagnation syndromes 2.17% and lastly are kidney deficiencies.The 20 syndrome types were analyzed thoroughly and analyzed by part,sites of diseased :kidney,liver,heart and spleen.Highest frequency of occurrence are kidney was 61.85%,liver 31.73%,heart 5.35%,and lastly spleen 1.07%.The disease elements: the most frequent occurrence is yin deficiency(71.27%),followed by16.41% of qi stagnation,8.21% of yang deficiency,1.94% of blood stasis,and the frequency of others are less than 1%,Analysis of Medication Rule: The useful drug frequency statistics of 368 prescriptions is made.The results showed that there were 163 drugs with a cumulative frequency of 4146.After frequency statistics of high-frequency drugs,their usage rate and frequency are calculated.There are 32 drugs with a usage rate of more than 10%.Among them,there are top 10 high-frequency drugs with a usage rate of more than 30%.They are listed in descending order: Rehmannia glutinosa Libosch.(Shudihuang),Cornus officinalis(Shanzhuyu),Radix paeoniae alba(Baishao),Dioscorea opposita Thunb..(Shanyao),Poria cocos(Fu ling),Angelica sinensis(Dagui),Ligustrum lucidum(Nuzhenzi),Anemarrhena asphodeloides(Zhimu),Moutan Cortex(Mudanpi)and Bupleurum Chinese(Chaihu).Analysis of efficacy classification of traditional Chinese medicine: they can be divided into 18 categories.Among them,tonifying drugs accounted for 41.82% of the highest frequency,followed by antipyretic drugs 16.62%,astringent drugs 9.02%,sedative drugs 8.83%,and diuretic drugs accounted for the fifth place.Other categories account for less than 5%.Statistical analysis of drug properties: cold drugs were used at most39.25%,1629 times,followed by warm drugs 26.77%,Statistical analysis of the flavor of medicine: sweet medicine is 40.68% at most,followed by bitter medicine 23.75%,bitter medicine 15.14%,sour medicine 9.74%,astringent medicine 4.87%,salty medicine 3.12%,light medicine 2.70.Statistical analysis of drug meridians: in 368 clinical prescriptions,the drugs mainly belong to the liver meridian 25.41%,followed by the kidney meridian 23.87%,the heart meridian 14.68%,and the spleen meridian 11.27%.Other meridians are less than10%.Drugs pair combination: Dioscorea opposita Thunb..and cornus officinalis,Dioscorea opposita Thunb.and Rehmannia glutinosa Libosch.,Phellodendri chinensis cortex and Anemarrhena asphodeloides,keel and oyster,Eclipta prostrata L.and Ligustrum lucidum.The top three drugs combinations are made of all different combinations of Rehmannia glutinosa Libosch.,Cornus officinalis and Dioscorea opposita Thunb..The top three of four drug combinations are made of all different combinations of Rehmannia glutinosa Libosch,Cornus officinalis,Dioscorea opposita Thunb.and poria cocos.Application of common drugs in different syndrome types.Liver and kidney yin deficiency syndrome: Rehmannia glutinosa Libosch.,Cornus officinalis,Dioscorea opposita Thunb,Radix paeoniae alba,Wolfberry.Kidney-yin deficiency syndrome: Rehmannia glutinosa Libosch.,Cornus officinalis,Poria cocos,Dioscorea opposita Thunb.,Moutan Cortex.Kidney deficiency and liver stagnation syndrome: Radix Rehmanniae Preparata,Bupleurum Chinese,Dioscorea opposita Thunb.,Cornus officinalis,Angelica sinensis.Drug groups.First group: Keel,Oyster and Schisandra chinensis.Second group:Anemarrhena asphodeloides,Phellodendri chinensis cortex,Epimedium,Ligustrum lucidum,Eclipta,Raw Rehmannia glutinosa Libosch..Third group: Fructus Tritici Ievis,Ziziphi Spinosae Semen,Salvia miltiorrhiza and Coptidis Rhizoma.Fourth Group: Radix paeoniae alba,Bupleurum Chinese,Atractylodes macrocephala,Angelica sinensis.Fifth Group: Moutan Cortex,Alismatis Rhizoma,Poria cocos,Cornus officinalis,Dioscorea opposita Thunb,Rehmannia glutinosa Libosch.,Lycii Fructus,Cuscuta chinensis,Tortoiseshell2.Acupuncture: Syndrome differentiation analysis: In 79 clinical documents,there are 12 syndromes after standardization: liver-kidney yin deficiency34.18%,kidney-yin deficiency 25.32%,yin deficiency and fire excess10.13%,kidney-yang deficiency7.59%,heart-kidney disharmony 5.06%.Site of diseased: kidney,liver,heart and spleen.The highest frequency is kidney 62.61%,followed by liver32.17%,heart 3.48%,and spleen 1.74%Analysis of acupoint regularity.Statistical analysis of acupoints: the frequency of acupoints in 79 documents was calculated,and the results showed that 73 acupoints were counted,with a total of 549 frequencies.After frequency statistics of high-frequency acupoints,their usage rate and frequency are calculated.There are 18 high frequency acupoints with a usage rate of more than 10%,of which the top 10 are in descending order of frequency: Sanyinjiao,Shenshu,Taixi,Guanyuan,Ganshu,Shenmen,Taichong,Zusanli,Neiguan,Qihai.Statistics of acupoint meridian classification: among the 73 acupoints selected,except 3 extra meridian acupoints,the remaining 70 acupoints are classified according to their respective meridians,involving the twelve meridians and the two channels of Ren and Du,with a total frequency of 531 times.The highest frequency is the bladder meridian of the foot taiyin(123 times,23.16%),followed by the kidney meridian of the foot shaoyin(78 times,14.69%),the Ren Channel(72 times,13.56%),the spleen meridian of the foot taiyin(66 times,12.43%),the stomach meridian of the foot yangming(43 times,8.10%).The statistics of the location of the acupoints are as follows: the location of the acupoints is divided into eight parts: head,chest,abdomen,waist,arm,hand,leg,and foot.The highest frequency of acupoints involving the waist and back is 134,24.41%,followed by the abdomen(108,19.67%).Statistical analysis of specific acupoints: Five Shu acupoints account for 22.64% of the total frequency,156 frequencies are the most commonly used specific acupoints,followed by Intersection point(21.48%,148 times),Source point(16.55%,114 times),Back Shu point(16.26%,112 times),Mu point(8.13%,56 times),Eight meridians intersection point(6.24%,43 times),collateral point(3.77%,26 times),Xiahe point(3.63%,25 times),Eight meeting points(1.16%,8 times),Xi point(0.15%,1 time)Statistical analysis of Five Shu points;The highest frequency is Shu Xue(68.59%,107 times),followed by He Xue(17.95%,28 times)and Jing Xue(6.41%,10 times).Two common combinations of acupoints: Taixi and Sanyinjiao,Guanyuan and Sanyinjiao,Ganshu and Shenshu,Shenmen and Sanyinjiao,Taichong and Sanyinjiao.Three acupoints combination : Taichong+Sanyinjiao+Taixi.Four acupoints combinations : Shenmen.Kidney-yin deficiency syndrome: Sanyinjiao,Taixi,Guanyuan,Shenshu,Zusanli Yin deficiency and fire hyperactivity syndrome:Sanyinjiao,Taixi,Shenmen,Shenshu,Zhaohai.Acupoint groups:First group:Shenshu,Ganshu,Xinshu,Pishu,Geshu,Yongquan.Second group: Taichong,Neiguan,Hegu,Shenmen,Taixi,Zusanli,Baihui,Sanyinjiao,Fuliu;Third group:Sishenchong,Yintang,Zhaohai.Fourth group: Zigong,Tianshu,Guanyuan,Qihai,Zhongwan,MingmenConclusion:1.Medicine.The therapeutic principle of Perimenopausal syndrome is using tonic method,tonifying the liver and kidney,nourishing yin and clearing away heat,simultaneously soothing the liver and regulating qi,and harmonizing yin and yang.The medicines are mainly used for nourishing Yin,blood and Yang,which have the effect of nourishing yin and blood and complement kidney yang,which is in line with the drug characteristics of "seeking yang in yin".The combination of antipyretic drugs,it can nourish yin of liver and kidney,nourish yin and clear heat due to deficiency,assist in soothing liver and relieving depression.The medicine mainly attributed to the liver meridian(Ganjing),the kidney meridian(Shenjing),the heart meridian(Xinjing)and the spleen meridian(Pijing).2.Acupuncture.The clinical thinking of Acupuncture and moxibustion for the treatment of menopausal syndrome: First,holistic concept,high-frequency use of acupoints such as Sanyinjiao at jiaohuixue,one point for the treatment of three meridians.Second,we should pay attention to "regulating the spirit",such as Baihui,Yintang,Shenmen and other acupoints can regulate mind and spirit.Thirdly,the efficacy of acupoints analyzed in this study has the functions of nourishing liver and kidney,strengthening kidney,regulating Chong Ren,and regulating yin and yang.Although there are some differences between the Chinese medicine chapter and the Acupuncture and moxibustion chapter,most of the analysis results are highly identical.The clinical thinking in the medicine and acupuncture and moxibustion chapters follow the therapeutic principles of nourishing the liver and kidney,strengthening the kidney,nourishing yin,clearing away heat and calming the heart,soothing the liver and regulating qi,regulating Chongren,and regulating yin and yang.