| Objective: To explore the advantages of integrated traditional Chinese and Western medicine,namely Daying-35 combined with kidney tonic and phlegm supplementation,in improving menstrual conditions,TCM symptoms,adjusting hormone levels,etc.,in order to provide more theoretical basis and treatment methods for clinical treatment,and further help solve the problems of irregular menstruation,decreased pregnancy rate,and endocrine disorders in patients with polycystic ovary syndrome in different periods(including adolescence and childbearing age).Methods: The study consists mainly of the following two parts.The first part is theoretical research: through the search and reading of relevant literature published in recent years,the author summarizes the multi-faceted understanding of PCOS in traditional medicine and modern Western medicine,including its etiology,pathogenesis and corresponding treatment options,and further discusses the pharmacological effects and clinical mechanism of use of kidney tonifying and phlegm prescription to treat PCOS.Clinical observation: According to the random number table method,it was divided into observation group(oral Dayin-35 + kidney tonic and phlegm formula)and control group(oral Dayin-35 + placebo),and each continued to treat each according to the proposed treatment plan for three months.Among them,there were 32 cases in the observation group and 31 cases in the control group,with a total of 63 patients.During the treatment,2 cases in the observation group and 1 case in the control group did not adhere to the treatment as required,so a total of 3 cases were shed,and finally 60 cases were statistically analyzed.The menstrual scores,hirsutism and acne,laboratory indicators(FSH,LH,LH/FSH,E2,T,AMH),safety indexes and TCM syndrome scores of the two groups before and after treatment were observed and recorded,and the menstrual cycle was followed up in outpatient or telephone for 3 months after discontinuation.The SPSS26 software is used to perform statistical analysis of the data and further draw core conclusions.Results: The differences in age,course of disease,menstrual score,hirsutism and acne,laboratory indicators(FSH,LH,LH/FSH,E2,T,AMH),and TCM syndrome scores of the first two groups were not statistically significant and comparable.1.Age: P>0.05 by independent sample t-test,the difference was not statistically significant,and there was no significant difference in age.2.Disease course: ranked sum test,P>0.05,the difference was not statistically significant,and there was no significant difference in the course of the disease.3.Menstrual score(cycle,period,menstrual flow):Period: After analysis,the observation group and the control group were compared before and after treatment,P<0.05,the difference was statistically significant.After treatment,P=1.000>0.05 between the two groups,The difference was not statistically significant.Menstrual period: After analysis,the observation group was compared before and after treatment,P<0.05,the difference was statistically significant;Intra-control group before versus after treatment,P>0.05,the difference was not statistically significant;After treatment,P=0.884 > 0.05 between the two groups,The difference was not statistically significant.Menstrual flow: Menstrual flow: After analysis,the observation group was compared before and after treatment,P<0.05,the difference was statistically significant;Intra-control group before versus after treatment,P>0.05,the difference was not statistically significant;After treatment,P=0.421>0.05 between the two groups,The difference was not statistically significant.It was suggested that the observation group could improve the menstrual cycle,menstrual period and menstrual flow of patients after treatment,while the control group could improve the menstrual cycle of patients,and the effect of improving menstrual period and menstrual flow was not significant.4.Hirsutistic signs: After analysis,the observation group and the control group were compared before and after treatment,P>0.05,the difference was not statistically significant.After treatment,P=0.767>0.05 between the two groups was not statistically significant.Signs of acne: After analysis,the observation group and the control group were compared before and after treatment,P<0.05,the difference was statistically significant.After treatment,P=0.002<0.05 between the two groups was statistically significant.It suggests that hirsutism did not improve significantly after treatment in both groups.After acne treatment,P=0.002<0.05 was statistically significant.It suggested that the observation group had better acne signs than the control group.5.TCM syndrome score: After analysis,the observation group and the control group were compared before and after treatment,P<0.05,the difference was statistically significant.It was suggested that the TCM syndrome scores improved after both groups of treatment.P=0.036<0.05 between the groups was statistically significant,suggesting that the observation group had a better effect than the control group.6.Laboratory indicators: LH,LH/FSH ratio,T,E2 decreased,and FSH value increased after treatment in the two groups.After analysis,the P<0.01 was statistically significant compared between the observation group and the control group before and after treatment.It also suggested that the observation group was better at reducing T(P=0.019)and AMH(P=0.045),and the two groups had similar efficacy in improving other hormone levels.7.Symptom efficacy determination: Compared with the symptomatic efficacy of the two groups after treatment,the effective rate of the observation group was 93.33%,and the effective rate of the control group was 76.67%.After the rank sum test,Z=-2.903,P=0.004<0.05 showed that the two groups had significant differences,and the observation group was better than the control group.8.Follow-up: Compared with the 3-month menstrual cycle days after the two groups stopped taking the drug,the effective rate of the observation group was 86.67%,and the effective rate of the control group was 73.33%.After the rank sum test,Z=-2.165 and P=0.030<0.05 showed that there were significant differences between the two groups,and the observation group was better than the control group.Conclusion: Daying-35 combined with kidney tonification and phlegm can improve the medical symptoms and acne signs of patients,and adjust their menstrual cycle,menstrual period and menstrual flow.Reduce the LH,LH/FSH ratio,T,E2,and increase the FSH value.There is no obvious liver and kidney function damage or adverse reactions in clinical application,and the safety is good and worthy of promotion. |
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