| Purpose: To observe the clinical efficacy of modified Sangjuyin the treatment of acute bronchitis with wind-heat offending lung syndrome in children,preliminarily evaluate its safety and effectiveness,and also analyse the etiology and pathogenesis and principle-method-recipe-medicines of this disease,so as to further provide theoretical support for the clinical treatment of acute bronchitis in children with internal treatment.Methods: 99 cases of children with acute bronchitis(wind-heat invading lung syndrome)were randomly divided into two groups;50 cases in the control group were treated with Dextromethorphan Sustained-Release Suspension and Acetylcysteine granules;49 cases in the test group were treated with modified Sangjuyin.After the treatment of 7 days,the clinical effects of the patients in the 2 groups were compared.Results:⑴In the clinical effect,the control group: 4 cases were cured,7 cases were significantly effective,24 cases were effective,15 cases were ineffective,the overall response rate was 70% and the overall significant rate was 22%;the test group:10 cases were cured,17 cases were significantly effective,16 cases were effective,6cases were ineffective,the overall response rate was 87.8% and the overall significant rate was 55.1%,which were statistical significance(P < 0.05),indicating that the test group was superior to the control group;the total effective rate of the cough symptom of control group was 78%,the effective rate of test group was 95.9%,indicating the improvement of cough symptoms of the test group was better than the control group;⑵There was no significant difference in gender,age,weight,height,course of disease,cough VAs value,cough severity,various main symptom scores(cough,expectoration,pulmonary signs),various secondary symptom scores(evil wind,fever,sore throat,dry mouth,nasal congestion runny nose,general malaise,diet,urination,dry stool)and main symptom scores,secondary symptom scores and total symptom scores before treatment between the two groups(P > 0.05),the difference has statistics significance;⑶ After treatment,the main symptom scores(cough,expectoration,pulmonary signs),secondary symptom scores(evil wind,fever,sore throat,dry mouth,nasal congestion runny nose,general malaise,diet,urination,dry stool)and main symptom scores,secondary symptom scores and total symptom scores were improved in the two groups,and the differences were statistically significant(P < 0.05),indicating that the two groups were effective in the treatment of acute bronchitis in children;⑷After treatment,the pulmonary signs,fever,dry mouth,nasal congestion runny nose,urine were not significantly improved in the two groups,and the differences were not statistically significant(P > 0.05),indicating that there was no significant difference in the efficacy of pulmonary signs,fever,thirst,nasal congestion runny nose,urination,etc.;the main symptom scores(cough,expectoration),secondary symptom scores(evil wind,sore throat,general malaise,diet,dry stool),main symptom scores,secondary symptom scores,total scores,cough severity and cough VAs values were improved,and the differences were statistically significant(P < 0.05).It indicated that the test group was superior to the control group in improving cough,expectoration,evil wind,sore throat,general malaise,diet,dry stool,main symptom score,secondary symptom score,total score,cough severity and cough VAs value.Conclusion:(1)Modified Sangjuyin can improve the severity of cough in children with acute bronchitis and relieve the pain of children;(2)Modified Sangjuyin can significantly reduce the total score of TCM symptoms of wind-heat offending lung syndrome in children with acute bronchitis and the scores of each TCM(cough,expectoration,evil wind,sore throat,general malaise,diet,dry stool),which has significant effect;(3)Modified Sangjuyin has good clinical efficacy in the treatment of acute bronchitis with wind-heat syndrome in children,without obvious adverse reactions,which is safe and reliable. |
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