Application Of Tiroflban Antithrombotic Therapy In Mechanical Embolectomy Of Acute Cerebral Infarction And Its Impact On Short-Term Prognosis

ObjectiveTo explore the application of tirofiban antithrombotic therapy in mechanical embolectomy of acute cerebral infarction and its impact on short-term prognosis.Materials and methodsSelect 100 patients with acute cerebral infarction who received mechanical embolectomy in our hospital from October 2019 to October 2021,and divide them into control group and drug intervention group according to different treatment methods.The control group was treated with conventional antithrombotic therapy combined with baiaspirin and clopidogrel after mechanical thrombectomy,and the experimental group was treated with tirofiban on the basis of the control group.Observe and compare the thrombolytic blood flow grade,nerve function injury,selfcare ability and short-term prognosis of the two groups.Results1.After treatment,the TICI blood flow grading of the experimental group was significantly better than that of the control group(P<0.05);The scores of the National Institute of Health stroke scale(NIHSS)of patients in the two groups were significantly lower than those in the experimental group(P<0.05);The score level of Barthel Index Scale(BI)was significantly higher than that of the experimental group(P;The Glasgow Outcome Scale(GOS)score of the experimental group was significantly higher than that of the control group(P<0.05),and the clinical mortality was significantly lower than that of the control group(P<0.05).2.There was no significant difference in the levels of oxidative stress factors before operation,48 hours after operation and at discharge between the two groups(P>0.05).The CRP and MDA at 48 h after operation were significantly lower in the experimental group than in the control group(P<0.05).The CRP and MDA before discharge were significantly lower in the experimental group than in the control group(P<0.5).3.There was no significant difference in SOD and GSH-Px between the two groups before operation(P>0.05).The SOD and GSH-Px at 48 h after operation were significantly higher in the experimental group than in the control group(P<0.05).SOD and GSH-Px C before discharge were significantly higher in the experimental group than in the control group(P<0.5).4.There was no significant difference in BDNF between the two groups before operation(P>0.05).The BDNF at 48 h after operation was significantly different from that before operation,and the experimental group was significantly higher than the control group(P<0.05).There was a significant difference between the experimental group and the control group before discharge,and the experimental group was significantly higher than the control group(P<0.5).There was no significant difference in GFAP and UCH-L1 between the two groups before operation(P>0.05),but there was a significant difference in GFAP and UCH-L1 48 hours after operation compared with that before operation,and the experimental group was significantly lower than the control group(P<0.05).There was a significant difference between the experimental group and the control group before discharge,and the experimental group was significantly lower than the control group(P<0.5).5.The total recanalization rate of patients in the control group was 78.0%,and the total recanalization rate of patients in the observation group was 90.0%.The total recanalization rate of patients in the observation group was significantly higher than that in the control group,and the difference between the two groups was statistically significant(P<0.05).The total effective rate of the experimental group was 96.00%,and the total effective rate of the control group was 82.0%.The experimental group was significantly higher than the control group.The difference between the two groups was statistically significant (2=5.629,P<0.05).ConclusionThe treatment of tirofiban combined with conventional basic antithrombotic drugs after mechanical embolectomy can effectively promote the vasodilation of patients with acute cerebral infarction,restore blood flow patency,promote the recovery of patients’ nervous function,effectively improve the self-care ability of patients,and effectively prevent the death of patients after treatment,with good clinical prognosis effect,which is worthy of further promotion in clinical practice.