The Relationship Between Serum Blood Lipid And Blood Glucose Levels With Cervical Cancer And Precancerous Lesions

Objective:Cervical cancer is one of the most common female malignancies and its morbidity and mortality remain high.High-grade squamous intraepithelial neoplasia(HSIL)is a precancerous lesion of cervical cancer,which can rapidly progress to cervical cancer if HSIL is not treated promptly.In recent years,the relationship between blood lipid,blood sugar and cancer has received extensive attention.The purpose of this study was to explore the correlation and diagnostic value between these indexes and the risk of cervical squamous cell carcinoma(SCC)and precancerous lesions,SCC staging,postoperative pathological features of SCC by detecting the levels of blood lipid,blood glucose and BMI in different populations.The results of this study will contribute to a better understanding of the pathogenesis of cervical cancer and precancerous lesions,as well as provide a simpler and cheaper marker for the diagnosis,prevention and prognosis of cervical cancer,contributing to the improvement of public health.Methods:According to the inclusion and exclusion criteria of this paper,women admitted to our hospital from January 2021 to June 2022 were selected as the study objects.Basic personal information,height,weight and other physiological data of each subject were collected,and the serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and fasting blood glucose(FBG)of patients before treatment were retrospectively collected.According to the final pathological results,the subjects were divided into SCC group,HSIL group,and control group with benign lesions(such as cervical inflammatory disease and low-grade cervical squamous intraepithelial lesions).To explore the correlation and diagnostic value of cervical squamous cell carcinoma and precancerous lesions by comparing the levels of blood lipid,blood glucose and BMI among all groups.In terms of data processing,SPSS software was used in this study for statistical analysis,including descriptive statistical analysis,t test,variance analysis,chi-square test,ROC curve analysis,etc.Pearson correlation coefficient or Spearman rank correlation coefficient were used to analyze the correlation of blood lipid,blood glucose and BMI with cervical squamous cell carcinoma and precancerous lesions.At the same time,sensitivity,specificity,positive predictive value and negative predictive value were calculated to evaluate the diagnostic value of each index for cervical squamous cell carcinoma and precancerous lesions.Results:(1)Serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and fasting blood glucose(FBG)levels were significantly different between the benign,HSIL and SCC groups(P<0.001),while low density lipoprotein cholesterol(LDL-C)levels were not significantly different among the three groups.(2)TC,TG and LDL-C were positively correlated with BMI,while HDL-C was negatively correlated with BMI.(3)The levels of TC,TG and FBG were positively correlated with the degree of cervical lesions(r_s=0.222,P<0.001;r_s=0.170,P<0.001;r_s=0.212,P<0.001),while HDL-C levels were negatively correlated with the degree of cervical lesions(r_s=-0.161,P<0.001).There was no significant correlation between LDL-C level and BMI and the degree of cervical lesions.(4)Logistic regression analysis showed that high levels of FBG,TC and TG as well as low levels of HDL-C were associated with the increased risk of HSIL and SCC,respectively.The OR values of high levels of FBG for the increased risk of HSIL and SCC were 2.333and 3.143,respectively.High levels of TC increased the risk of HSIL and SCC by 1.899 and 5.047,high levels of TG increased the risk of HSIL and SCC by1.79 and 2.745,and low levels of HDL-C increased the risk of HSIL and SCC by 5.003 and 2.588,respectively.All of these differences were statistically significant(P<0.05).After adjusting for relevant factors,these differences were still statistically significant(P<0.05).High levels of LDL-C and overweight or obese BMI did not show an effect on disease risk.(5)There was no significant difference in serum indexes between postoperative stage and postoperative pathological feature groups of SCC.(6)The area under ROC curve of the combined diagnostic system based on TC,TG,LDL-C,FBG and HDL-C levels was 0.756(95%CI 0.700-0.811,P<0.001),the sensitivity was 79.1%,and the specificity was 66.3%.Conclusions:1.This study found that serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and fasting blood glucose(FBG)were correlated with cervical intraepithelial neoplasia(HSIL)and cervical squamous cell carcinoma(SCC).The serum levels of TC,TG,LDL-C and FBG were gradually increased,while HDL-C was gradually decreased with the severity of the lesion.2.There was no correlation between body mass index(BMI),an indicator of obesity,and cervical diseases,but there was a correlation between BMI and lipid indexes.3.High levels of TC,TG,FBG and low levels of HDL-C may be risk factors for cervical lesions.However,in this study,no significant correlation was found between serum indexes and the staging and postoperative pathological features of cervical cancer.4.This study also found that the combined diagnostic system formed by the levels of TC,TG,LDL-C,FBG and HDL-C has certain diagnostic value for the diagnosis of cervical squamous cell carcinoma.