| Purpose:Investigate,analyze,and study the characteristics and distribution characteristics of TCM constitutions of POI patients,factors affecting the quality of life of POI patients,and the correlation between TCM constitutions and quality of life of POI patients,so as to provide clinical basis for "discrimination and treatment" of POI.Method:The research method was designed by convenience sampling.Select 223 POI patients who visited the Gynecology Clinic of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from December 2021 to December 2022;survey the patients and fill in the "Basic Information Survey Form","Traditional Chinese Medicine Constitution Classification and Judgment Form","Menopausal Symptom Evaluation Form" Scale(MRS)" "World Health Organization quality of life measurement short form(WHOQOL-BREF)";data entry;SPSS 26.0 statistical software was used for relevant statistical analysis.Result:A total of 223 POI samples were investigated,analyzed and studied.1.The most common TCM constitutional characteristics are yang-deficiency constitution(101,45.29%),qi stagnation constitution(77,34.53%),and phlegm-dampness constitution(65,29.15%).2.Individuals with single constitution(88,39.46%)mainly have yang-deficiency constitution(27,30.68%),qi-stagnation constitution(18,20.44%),and yin-deficiency constitution(15,17.05%).3.The main constitution types of those with two kinds of physical characteristics(63,28.25%)are:yang deficiency and qi stagnation(10.15.87%),yang deficiency and yin deficiency(8,12.70%),yang deficiency and blood stasis(7,11.11%),yang-deficiency and qi-deficiency constitution(7,11.11%);and those with 3 constitutional characteristics(47,21.08%),and 4 or more constitutional characteristics(11.21%).4.For those with single constitutional characteristics,the FSH level of yin-deficiency constitution was higher than that of yang-deficiency constitution and qi-stagnation constitution(P=0.037);the E2 level of yang-deficiency constitution was higher than that of yin-deficiency constitution and qi-stagnation constitution(P=0.045).Occupational differences among the 3 groups of physiques were different.Those with yang-deficiency constitution and qi-stagnation constitution both accounted for more than 60.00%,and those with yin-deficiency constitution accounted for 33.00%.5.Analyze the scale scores of single POI patients with yang-deficiency constitution,qi-stagnation constitution,and yin-deficiency constitution with more than 15 cases.There are differences in MRS scores among the three groups,and the total score of yin-deficiency constitution is higher than that of yang-deficiency constitution and qi-stagnation constitution The two groups(P=0.018),the difference is mainly manifested in the two dimensions of psychological sensation and physical sensation;there are differences in the scores of WHOQOL-BREF scale among the three groups,and the total score of yin-deficiency constitution is lower than that of yang-deficiency constitution and qi-stagnation constitution(P=0.036),the difference is mainly manifested in the two dimensions of physiology and psychology.6.There was no significant difference in age,BMI,course of disease,and pregnancy times between the single constitution group and the combined constitution group(P>0.05);Those with combined constitution(P=0.048);there was no significant difference in occupation,education,assisted reproductive history and HRT treatment history between the single constitution group and the combined constitution group(P>0.05).7.There was no significant difference in MRS scale scores between the single constitution group and the combined constitution group(P=0.535);the WHOQOL-BREF score of the single constitution group was slightly higher than that of the combined constitution group(P=0.043),and the difference was mainly reflected in the psychological dimension.8.There was no significant difference in the biased constitution distribution of POI patients in different age groups(P>0.05);those with a shorter course of disease tended to have yang-deficiency constitution(OR=0.908,95%CI=0.735-1.083).Those with a history of assisted reproductive therapy tended to have yin deficiency(OR=2.450,95%CI=1.124-5.340).The higher the BMI index,the more likely patients are to have phlegm-damp constitution(OR=1.299,95%CI=1.048-1.611).Persons whose occupations are employees(OR=15.524,95%CI=2.795,86.238),have high FSH levels(OR=1.026,95%CI=1.006-1.647),and high LH levels(OR=1.061,95%CI=0.931-1.192)tend to have Qi depression constitution.Those with higher BMI(OR=0.915,95%CI=0.843-0.992)were less likely to have qi stagnation constitution.9.The total score of the MRS scale of the research sample was normally distributed.Whether it is yin-deficiency constitution(B=1.594,95%CI=-0.605-3.794),FSH level(B=0.054,95%CI=0.006-0.101),significantly positively predicts the sample MRS scale score;E2 level(B=-1.815,95%CI=-0.096--0.010),significantly negatively predicting the sample MRS scale score.10.The total scores of the WHOQOL-BREF scale of the research samples were normally distributed.To predict the quality of life of the sample;educational background(B=-1.354,95%CI=-2.881-0.173),occupational content(B=-2.002,95%CI=-3.980--0.024),FSH level(B=-0.072,95%CI=-0.106--0.038),yin-deficiency quality(B=-1.789,95%CI=-4.487-1.091),significantly negatively predict the quality of life of the sample.11.The scores of MRS scale and WHOQOL-BREF scale were moderately negatively correlated at the 0.0001 level(both sides)(r=-0.5339,P<0.0001).12.According to FSH=40IU/mL as the threshold,the patients in the sub-sample were divided into POI initial stage group and POF group for stratified analysis.There was no statistical difference in FSH level and other characteristics between the two groups.The scores of MRS scale and WHOQOL-BREF in the POF group were higher than those in the early POI group(P=0.001).There was a difference in single constitution between the two groups.The yang-deficiency constitution in the POI initial stage group was more than that in the POF group(P=0.037),and the qi-stagnation constitution was less than that in the POF group(P=0.034).Conclusion:1.Yang-deficiency constitution,qi-stagnation constitution and yin-deficiency constitution are the most important single constitutions of POI patients;phlegm-dampness constitution is the most important combined constitution of POI patients.2.Yang-deficiency constitution is a predisposing constitutional characteristic of POI patients in the early stage of onset;as the course of the disease increases,the constitutional characteristic of yang-deficiency decreases and gradually transforms into other constitutional characteristics.The constitution of patients with a history of assisted reproductive therapy tends to transform into yin-deficiency constitution;the constitution of patients with high BMI level tends to appear phlegm-damp constitution;high work and life pressure and elevated basal hormone levels may lead to the generation of qi stagnation constitution in POI patients.3.The perimenopausal syndrome-like symptoms were more severe in POI patients with yin deficiency constitution,and their quality of life was low.4.Parity and history of HRT positively affect the quality of life of POI patients;factors such as work,life pressure and hormone levels negatively affect the quality of life of POI patients.5.The MRS scale can be used to evaluate the degree of perimenopausal syndrome-like symptoms and quality of life in POI patients;the higher the MRS scale score,the more severe the symptoms and the lower the quality of life of the patients.6.The constitutions of patients with POI in the early stage were mainly yang-deficiency and yin-deficiency constitutions;the constitutions of POF patients were mainly qi-stagnation constitutions and yin-deficiency constitutions. |
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