| Objective:Based on the concept of integrating traditional Chinese medicine with traditional Chinese medicine,this paper combined modern medicine treatment of thyroid cancer with traditional Chinese medicine to explore the etiology,pathogenesis and treatment of thyroid cancer.The main purpose of this study is to observe whether Jiawei Xiaoyao Powder can improve the discomfort symptoms of patients with liver-stagnation and spleen-deficiency syndrome after thyroid cancer surgery and its influence on thyroid hormone,globulin and other indicators,in order to provide reference and theoretical basis for the treatment of thyroid cancer after Chinese medicine surgery,and make certain contributions to the modernization of traditional medicine.Methods:Patients were randomly divided into treatment group and control group with 30 patients in each group by single blind method and random number table method.The control group was treated with levothyroxine sodium tablets,and the observation group was treated with levothyroxine sodium tablets combined with supplemented Xiaoyao Powder decoction for 28 days.The dose of levothyroxine sodium tablets in the two groups was adjusted according to the thyroid function level of patients according to the guidelines for TSH inhibition therapy.The Karnofsky score,SAS score,TCM clinical syndrome score,thyroid function,thyroglobulin,thyroglobulin antibody changes of the two groups were observed before and after treatment.Through the comparison between the treatment group and the control group,before and after treatment,to observe the therapeutic effect of Jiawei Xiaoyao SAN decoction on thyroid cancer after operation.Results:1.Karnofsky score:Karnofsky score before treatment in both groups was not statistically significant(P>0.05)and was comparable;Karnofsky score in the observation group improved after treatment compared with that before treatment,and the difference was statistically significant(P<0.05),indicating that the quality of life in both groups improved after treatment compared with that before treatment,and the improvement in the observation group was better than that in the control group.SAS score:SAS score of both groups before treatment was not statistically significant(P>0.05),SAS score of both control group and observation group decreased after treatment,and the difference was statistically significant(P<0.05),indicating that the quality of life of patients in both groups improved after treatment,and the improvement of the observation group was better than that of the control group.3.Efficacy of TCM symptoms:After treatment,the total effective rate was 64.29%in the control group and 96.43%in the observation group,and the difference between the two groups was statistically significant(P<0.05).4.TCM evidence points:before treatment,there was no significant statistical difference between the TCM evidence points of the two groups(P>0.05);after treatment,the total TCM evidence points of both groups decreased compared with those before treatment,and the difference was statistically significant(P<0.05),and the decrease in the total TCM evidence points of the observation group was significantly greater than that of the control group.Before treatment,the individual TCM symptoms scores of both groups were not statistically significant(P>0.05),but after treatment,the symptoms of neck discomfort,tiredness and fatigue,chest pain,depression,lack of food and dullness,intestinal turn and yagging,and loose and unpleasant stools were improved in both groups,and the difference was statistically significant(P<0.05).Compared with the control group,the differences in neck discomfort,tiredness and fatigue,chest pain,depression,poor appetite and dullness,and intestinal discomfort were statistically significant(P<0.05),and the improvement of the above symptoms was significantly better than that of the control group.In terms of loose and unpleasant stools,the differences between the control and observation groups after treatment were not statistically significant(P>0.05).Overall,the symptoms of neck discomfort,tiredness and fatigue,chest pain,emotional depression,low food intake and dullness,and intestinal turning yawning were significantly improved in both groups after treatment,and the improvement in the observation group was better than that in the control group.5.Thyroid function,thyroid binding globulin and antibodies:Before treatment,there was no statistical difference in FT3,FT4,TSH and Tg between the two groups(P>0.05),and Tg-Ab was statistically different.After treatment,there was no statistically significant difference between the control group and the observation group in FT3,FT4,Tg,Tg-Ab(P>0.05),and after treatment,there was a statistically significant difference in TSH between the two groups(P<0.05).6.Safety:During the observation period of this study,no adverse events such as vomiting and drug allergy occurred in both groups before and after treatment,and no significant abnormalities were observed in patients’ liver and kidney functions and vital signs after treatment.Conclusion:1.Jiawei Xiaoyao Powder can effectively improve the clinical symptoms of liver depression and spleen deficiency syndrome such as neck discomfort,chest and hypochondriacal distending pain,fatigue and fatigue,emotional depression,intestinal rotation of yanqi after thyroid cancer surgery,and can significantly improve the quality of life of patients.The therapeutic effect is better than that of Unimethylate alone after operation.2.In terms of controlling thyroid hormone levels,Jiawei Xiaoyao SAN can not completely replace Youmethylate.3.Modified Xiaoyao Powder is safe and feasible,and no obvious adverse events occurred during the observation period,so it can be used in clinical treatment. |
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