Sequence Variation In The Collagen I And XI Genes And Its Polymorphisms Are Associated With Susceptibility To Keloid Disease

Keloid (KD) is a dermal fibroproliferative tumor of unknown aetiology, also unique to humans frequently met in plastic surgery. Evolving from minor injury such as sting, acne or punching in ear lobe or burn, wound or operation, it can lead to not only disfigurement, but also dysfunction of joints, or even worse, of organs. Treatment of keloid disease at present involves local medicine application, which can only reduce clinical syndrome such as pains and itch, or surgical operation, which demands great caution because it may, if other measures not taken, recur quickly after the encision and spread beyond the margin of the original wound, thus undermining the treatment.Clinical observation shows that it is an attributive of certain constitution, i.e., different patients have different result for the wound healing, and the transformation difference following tissue wound is expressed in that the scar of some patients heals while that of others develops into keloid. That is more related to his/ her inheritance than to outsider factors such as cause of the wound or infection. Though much has been done with regard to the aetiopathogenesis and treatment of KD from different aspects such as surgery, genetics, pharmacology and molecular biology, etc., the exact aetiopathogenesis and an efficacious treatment are not yet known to date. The pathological principle underlying the...