The Clinical Observation: Using Integrated Chinese And Western Medicine Treat Polycystic Ovary Syndrome (PCOS) Induced Infertility

Object:Polycystic ovary syndrome is a kind of endocrine disease that with different causes and polymorphism clinical manifestation. Moreover, PCOS is also a main reason that causes infertility because of not having ovary sends.The thesis intends to divide the PCOSⅠinto kidney efficiency and blood stasis and PCOSⅡinto spleen efficiency and blood stasis, on the basis of the researches of diseases and actual examples. Moreover, the author also intends to adopt her tutor's two excellent experiences-PCOSⅠmethod and PCOSⅡmethod to have a thorough study on PCOS 2, thus exploring the influence of the two methods on PCOS 2, including its clinical manifestations, inner incretion hormone, the ovary sends'rate, the pregnancy rate and the general effect, and instructing a clinical basis on the development of Chinese medicine. Methods:The author has not only divided the infertility caused by PCOS into obese and non-obese, on the basis of the established researches and the author's actual experience, but also has adopted the corresponding way of PCOS 1 to cure PCOSⅠand PCOS 2 for PCOSⅠon the basis of the research of CC, which helps to speed up the ovary sends.Clinical research of PCOSⅠ(Non-obese):A Case standards into line with PCOSⅠdiagnostic standard and kidney deficiency and blood stasis dialectical standard, the age of 25-year-old to 35-year-old married in 60 cases. According to the random distribution principle, it is divided into the treatment group (combination of Chinese and Western group) and the contrastive group (WM group) of the 30 cases.Treatment group and menstruation or progesterone withdrawal bleeding:have a temperature measurement basis at the first day, take the medicine clomiphene capsules (CC) after five days, once daily,50 mg orally each day for five days at the same time, plus the PCOS2 (i.e. the author's tutor Professor You Zhaoling's experience), oral. Treatment group and the control group were three of the menstrual cycle for treatment with a course of treatment and an efficient statistics. The observation side PCOS1 method plays a role in the clinical symptoms, endocrine hormone, ovulation rate, pregnancy rate and the total effect of PCOSⅠ PCOSⅡtype (obese) Clinical Research:A Case standards into line with PCOSⅡdiagnostic criteria and spleen deficiency and blood stasis standards, the age of 25-year-old to 35-year-old married in 60 cases. According to the random distribution principle, it is divided into the treatment group (combination of Chinese and Western), the control group (WM group) of the 30 cases. Treatment group and menstruation or progesterone withdrawal bleeding:have a temperature measurement basis at the first day, take the medicine clomiphene capsules (CC) after five days, once daily,50 mg orally each day for five days at the same time, plus the PCOS2 (i.e. the author's tutor Professor You Zhaoling's experience), oral, and the remaining treatment and observation has the same clinical study with PCOSⅠtype (non-obese).Result:1. PCOSⅠinduced infertility Clinical Study Results(1) The pregnancy rate of treatment group 63%,the total efficiency was 90%. The pregnancy rate of control group46.7%,the total efficiency was 73.3%. Using statistical test, the data showed statistical significance(P＜0.05)(2) Comparison of the two groups after treatment, the treatment group in amending the menstrual cycle, releasing lumbosacral pain and chest distress, as well as lower abdomen pain, vaginal discharge volume, sleepiness was superior to the control group. Statistically, there were significant differences (P＜0.05), Comparison of effects in TCM syndrome:the total efficiency in treatment group was 63.3%.33.3% of the control group. There were statistical differences (P＜0.05),(3) Changes in level of endocrine:compared endocrinic hormones showed statistical differences in treatment group before and after treatment (P＜0.05), the level of T and LH decreased significantly, E2 increased. Although in the control group some reproductive hormones changed after treatment, there were not statistical significance P＞0.05(4) The rat of treatment group was 85.5%, The rat of control group was 28.4% There were statistical significance between tow grouos.(P＜0.05)2 PCOSⅡtype (obese) Clinical Study Results(1) Clinical Observation on effect:The pregnancy rate of treatment group 46.7%,the total efficiency was 76.7%. The pregnancy rate of control group23.3%,the total efficiency was 46.7%. Using statistical test, the data showed statistical significance(P＜0.05)(2) clinical performance and TCM syndrome:Compared between the two groups after treatment, the treatment group in amending the menstrual cycle, releasing lumbosacral pain and chest distress, as well as lower abdomen pain, vaginal discharge volume, sleepiness was superior to the control group. Statistically, there were significant differences (P＜0.05). Comparison of effects in TCM syndrome:the total efficiency of 63.3%* in the treatment group, it was 33.3% in the control group. There were statistical differences (P ＜0.05)(3) Changes in level of endocrine:compared endocrinic hormones showed statistical differences in treatment group before and after treatment (P＜0.05). The levels of T and INS were declined markedly. Although in the control group some reproductive hormones changed after treatment, there were not statistical significance P＞0.05.(4) The rat of treatment group was,39.5% The rat of control group was 19.0% There were statistical significance between tow grouos.(P＜0.05)Conclusion:The intervention of PCOSⅠcan not only improve the general effect of PCOSⅠ, but also can effectively increase the pregnancy rate, reaching the purposes of a freely balanced menstruation and an unexpected pregnant.PCOSⅠcan significantly decrease the following symptoms in PCOSⅠ:an abnormal menstrual cycle, the menstrual color of anomaly, the abnormal quantity of menstruation, abdomen pain, dizziness, lumbosacral pain, acne and dry mouth. Moreover, it has a noticeable improvements on the tongue. However, it has no improvements in furry because of a short duration.PCOSⅠmethod can rapidly decrease the serum endocrine-T and LH of the patients who have PCOSⅠ(non-obese). On the other hand, it increases its E2. moreover, the ratio of LH/FSH is lower down before taking treatment, which implies that PCOSⅠmethod can improve the ovarian function, regulate the hypothalamic-pituitary-an ovarian axis' functions and correct the disorder endocrine environment.PCOSⅠmethod:it can increase the ovulation rates and ovulation sends for PCOSⅠ(non-obese) type.PCOSⅡcan increase both the total effect of PCOSⅡand effectively improve the pregnancy rate. However, in comparison with PCOSⅠ, PCOSⅡhas an obviously lower pregnancy rateThe intervention of PCOSⅡcan significantly improve the abnormal menstrual cycle, the menstrual color, the abnormal quantity, the abdomen pain, Chest Wan Man nausea, vaginal discharge volume, sleepiness, lumbosacral pain and other clinical manifestations. However, it only has a little improvement in the obesity, which may be related to the short duration.By lowering insulin levels of the PCOSⅡ, PCOSⅡcan improve peripheral insulin's resistance, and regulating glucose and lipid metabolism in patients with PCOS to improve local abnormal ovarian endocrine status and lower the levels of androgen, thus making the ovulation function recovered, ovulation rate increased and reproductive function improved.To PCOSⅠ, PCOSⅡhas a lower pregnancy rate, and while just adopting CC for treatment, PCOSⅡhas a even lower pregnancy rate. Moreover, it may be more complex than obesity exacerbating hyperinsulinemia, thus resulting in excessive androgen and producing a more complex PCOS endocrine.In conclusion, the study is based on differential treatment of the patients identified on the basis of governance, with different types of herbs on PCOS conduct of governance. Chinese medicine can balanced the PCOS patients'inner irregular environment to promote the recovery of their reproductive function.