| BackgroundWith the rapid socio-economic and technology developments in the modern society where competition, increasing work, study pressure and irregular eating habits which is increasing chronic fatigue in patients. The cause of chronic fatigue syndrome in pathology and pathogenesis is unclear, generally believed that is related to infection with the virus, the immune system and the endocrine system activity abnormalities. Speculated that chronic fatigue syndrome may include psychological stress, interpersonal relationships, hypothalamus and pituitary, adrenal axis abnormalities, hormone disorders, neurological defects, immunological abnormalities, and infection-related. Without specific diagnostic indicator for chronic fatigue syndrome is a main reason that is not effective in clinical treatment. Therefore, using acupuncture for prevention and treatment of chronic fatigue syndrome is an effective way in clinical significance.ObjectiveIn this study, patients with chronic fatigue syndrome are used by acupuncture for the clinical study. To explore acupuncture and electrical acupuncture for chronic fatigue syndrome of mechanism action, which provide a theoretical basis for a treatment of chronic fatigue syndrome. MethodsA literature review in an ancient and modern Chinese medicine practitioner focused on chronic fatigue pathogenesis and treatment. There was acupuncture treatment of chronic fatigue in clinical research and acupuncture in chronic fatigue mechanism of research. Meanwhile, modern physicians on chronic fatigue and chronic the pathogenesis of fatigue syndrome, chronic fatigue syndrome intervention were also discussed.The clinical study was performed on patients of chronic fatigue syndrome, according to inclusion and exclusion criteria selected cases of 60 cases by random were assigned to the acupuncture group (group A), sham acupuncture group (group B). Two groups were treated 3 days per week, and a total of 2 weeks of treatment. The World Health Organization Quality of Life Form (WHOQOL-BREF) and four factors, Chalder 14 fatigue total score (FS-14), Chinese Syndrome Rating Scale score were as a clinical assessment index, respectively before treatment and after 7 days,14 days,21 days for evaluation and treatment 21 days.The experimental study was performed on 40 adult SD rats which were randomly divided into normal group (group A), model group (group B), acupuncture group (group C) and Electric Acupuncture group (group D). In A, B, C groups, the rats were swimming in cold water (16±1)℃about 8 mins and got a tail stimulation for 10 days, resulting in a rat model of chronic fatigue. Acupuncture group (group C) was using ZuSanLi and TaiXi in 10 days consecutively. EA group (group D) acupuncture was using ZuSanLi and TaiXi, which the needle handles accessing with WQ-6F of electric acupuncture apparatus of voltage 4.5V, density wave and frequency 2-20Hz, intensity of local skin and muscle to quiver slightly for 10 days consecutively. And the rats were observed on the 1st,5th,10th of weight, Open-field test, strive to swim and tail suspension test. After the treatment, the mice were killed, and calculate the spleen index, heart index and liver index. Results1. The clinical studyBefore the treatment, there was no significant difference of WHOQOL-BREF score, WHOQOL-BREF physical score, WHOQOL-BREF psychological score, WHOQOL-BREF social relationships score, WHOQOL-BREF score in the field of environment, FS-14 score, Chinese Medicine syndromes rating scale score between two groups (P＞0.05).There was a significant difference in Acupuncture group at 7th day,14th day,21st day of WHOQOL-BREF total score comparing with 0 day (P＜0.01). And Acupuncture group compared with sham acupuncture group had a significant difference (P＜0.01).There was a significant difference in Acupuncture group at 7th day,14th day,21st day of WHOQOL-BREF physical score comparing with 0 day (P＜0.01). And acupuncture group compared with sham acupuncture group had a significant difference at 14th and 21st day (P＜0.01).There was a significant difference in Acupuncture group at 7th day,14th day,21st day of WHOQOL-BREF psychological score comparing with 0 day (P＜0.01). And acupuncture group compared with sham acupuncture group had a significant difference at 14th and 21st day (P＜0.05).Two groups were observed before the treatment, and WHOQOL-BREF social relationship factor scores were increased. But there was no statistical significance at the 7th,14th and 21st day (P＞0.05).There was a significant difference in Acupuncture group at 7th day,14th day,21st day of WHOQOL-BREF score in the field of environment comparing with 0 day (P＜0.01). And acupuncture group compared with sham acupuncture group had a significant difference at 14th and 21st day (P＜0.05).There was a significant difference in Acupuncture group at 7th day,14th day,21st day of FS-14 score comparing with 0 day (P＜0.01). And acupuncture group compared with sham acupuncture group had a significant difference at 14th and 21st day (P＜0.01). There was a significant difference in Acupuncture group at 7th,14th,21st day of TCM syndrome rating score comparing with 0 day (P＜0.01). And acupuncture group compared with sham acupuncture group had a significant difference at 14th and 21st day (P＜0.01).According to TCM syndrome effective rate efficacy compared two groups; the effective rate of group A was 88.89%. And the effective rate of group B was 19.23%. There was a significant difference between Acupuncture group and the sham acupuncture group (P＜0.01). 2. The Experimental resultsThere was no significant difference of weight, Open-field test, tail suspension test and exhaustive swimming time between four groups (P＞0.05).The results of exhaustive swimming test showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at the 5th,10th day (P＜0.01).The results of Open-field centre of retention time showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at the 5th,10th day (P＜0.01).The results of Open-field number of horizontal movement showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at the 5th,10th day (P＜0.01).The results of Open-field number of vertical movement showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at the 5th,10th day (P＜0.01).The results of Open-field vertical movement of time showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at 10th day (P＜0.01).The results of tail suspension time showed that there was a significant difference comparing with the model group and two other groups which were acupuncture and EA group at 10th day (P＜0.05).Conclusion Acupuncture intervention in chronic fatigue syndrome had significant clinical efficacy for patients which were an ideal method. The mechanism of acupuncture and electro-acupuncture of chronic fatigue rat model includes in improving mice'abnormal behavior, regulating its spleen ratio and heart ratio. |
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