The Research Of The Treatment For Chronic Prostatitis By Reforcing Qi

BACKGROUNDS: These days the incidence and the rates of recrudescence of chronic prostatitis (CP) are high. It is fearfully difficult to cure CP. Its pathogeny and pathogenesis still have not been clear. It has been short of perfect preparation of Chinese Traditional Medicine for curing CP in clinic. Therefore empoldering the effective Chinese patent medicine to treat CP and revealing its mechanism have an important significance. The thesis is one of the clinical and experimental researches of curing CP with nanmiqing. In the former phases, the study on effectivity,toxin and part mechanism of nanmiqing treating CP had been done. It showed that Nanmiqing has the functions of Clearing away heat and promoting diuresis, promoting blood circulation by removing blood stasis and replenishing Qi. It has a credible curative effect with little toxic reactions and side-effects. On the base of above research,the thesis deeply studied curative effect and its mechanism of replenishing Qi in treating CP. It is hopeful to perfect the research of the treatment for CP by Nanmiqing decoction.OBJECTIVE: To provide theoretical basis for the treatment of chronic prostatitis (CP) by reinforcing Qi through widely collecting past and present medicine reference material and reveal the mechanism through the clinical and experimental researches, so as to guide the choice of the medicine in treatment of CP in clinic.MATERIAL AND METHOD: In clinic research we chosed 74 cases of CP patients and randomly divided them into 2 groups. 42 cases as curing group NanMiQing (group A),32cases as QingHua control group(group B).Above two groups were separately treated them with decoction of NanMiQing (NMQ) and decoction of QinReHuaYu (QRHYM) (Clearing-away heat &Promoting blood circulation by removing blood stasis). EPS-Rt including PH, FAT and Zn ofEPS from the two groups of patients with CP were examined, the scoring(NIH-CPSI) of CP symptoms were evaluated before and after treatment.In the experimental research we used colitoxin to make the rat model of chronic protatitis and divided 44 SD male rats randomly into 4 groups: normal group (group A), model group(group B), QingHua group (group C), and NMQ group (group D). and separately treated the rats through pouring into their stomach with QingHua decoction, NanMiQing decoction by contrasting with two groups of normal and model. After treating 25 days we observed three physical symptom and pathological tissue slices of prostate of rats,and in the rats' blood we tested the level of AGP, CuZn-SOD, IL-6,TNF- a ,IgG and IgM. Through scientific statistics we analyzed the meaning of every index used in the experiment.RESULT: NanMiQing decoction can remarkably improve the inflammation damage of the rats' prostate; reduce the abnormally high level of IL-6. TNF- a and ACP; romote the level of CuZn-SOD that can resist inflammation and protect body; promote the level of IgG and IgM that can represent the immunocompetence. The function of NanMiQing decoction was remarkably more advantageous than the medicine of compared groups.CONCLUSION: NanMiQing decoction made by some Traditional Chinese Medicine which have the function of clearing away heat and promoting diuresis, promoting blood circulation by removing blood stasis and replenishing Qi is the efficiency prescription to cure experimental chronic prostatitis of rats. Deficiency of Qi is a kind of important pathogenesis of CP.And Reinforcing Qi is one of important treatments to cure CP.