The Research Of MaiLuoNing Injection On Renal Toxicity

MaiLuoNing injection, made from Traditional Chinese Medicine, which has been most widely used in China. During long-term clinical practice usage, there was some information in clinical reports which suggested that it could improve patients' kidney function. While other data drew a reverse document conclusion.In this paper, we aim to show the true effect of MaiLuoNing injection to kidney function by pharmacological method, and provide some useful information to physician.According to our study methods and research purpose, the paper is divided into four parts:The first part, we test the effect of MaiLuoNing injection on the kidney of normal rats. In this part we want to know whether MaiLuoNing injection has direct toxicity to normal renal tissue.Secondly, we study the effect of the injection on the renal failure rats. According to the difference of the renal failure mechanism we choose three models.1. Acute renal failure caused by glycerin.2. Acute renal failure caused by gentamicin (GM).3. Chronic renal failure caused by AdenineFor the clinical pathogeny of acute renal failure, we adopt different administration speed of MaiLuoNing injection to anesthetic dog to investigate the influence of the injection on blood flow kinetics in the third part.The fourth part, the relationship between blood pressure fall and renal perfusion speed decline in isolated rat renal perfusion method. This segment can be divided into two parts.1. Ascertain the methodology of isolated rat renal perfusion. Probed the optimal pressure and perfusion conditions and interferences and try to establish a method mode in the part.2. Study the relationship of the drug perfusion pressure and perfusion flux.