Curative Effect Of Oxycodone Hydrochcoride Controlled-release Tables And Oxycodone-acetaminophen Tables On Moderate And Severe Cancer Pain

Objectives:To observe the analgesic effect and adverse effects of oxycodone hydrochcoride controlled-release tablets(Oxycontin) and oxycodone-acetaminophen tablets(Tylox) on moderate and sever cancer pain were selected.Methods:A total of 50patients with oderae and severe cancer pain selected,every group had 25patients.Group A was treated with Oxycontin tablets,and Group B was treated with Tylox tablets.Evaluated outcomes included analgesic effect,scales of the functional assessment of quality of life and side effects.All patients received this therapy for 2 weeks.Results:(1) Easement of pain:PR of group A was higher than Group B on the 7^th and 14^th day;CR of group B was higher than Group A on the 7^th and 14^th day.(2)About the improvment of the functional assessment of quality of life,Group B was better than Group A on the symptom of pain.(3) Group A and Group B had the same adverse effect rate.Conclusion:The Group of oxycodone-acetaminophen tablets had the higher CR than the group of oxycodone hydrochcoride controlled -release tablets on the symptom of pain about the improvment of the functional assessment of quality of life.Both of them had the same adverse effect rate.