The Relationship Between The Related Factors Of Carotid Atherosclerosis And The Cerebral Infarction

IntroductionCerebral infarction(cerebral infarction,CI) is the focal brain tissue necrosis or cerebral softening.It's coursed by the ischemia,hypoxia At present,cerebral infarction has become the main reason that the old pepple are disabilities and dead.At home and abroad A large number of studies from home and abroad confirm that carotid atherosclerosis is the main reason and one of the most dangers for the CI.And it is related closedly to the cerebral infarction's happening development and the place of CI.In recent years,carotid atherosclerosis,as a number of clinical trials of cardio-cerebral vascular diseases as a "surrogate" has become reflected in the body of atherosclerosis lesions in a window.Many studies have shown that cerebral infarction in patients with carotid artery - the intima-media thickness was significantly thicker, leading to partially or completely blocked carotid artery,so that distal slow down the formation of a low perfusion pressure perfusion infarct;plaque off the lead to thrombosis cerebral infarction.Clinical studies have proven that the most dangerous reasons that caused carotid artery atherosclerosis are high blood pressure,male,high blood lipids,fibrinogen increased,hyperuricemia and diabetes,smoking,and so on. Please know enough about the situation of carotid atherosclerotic plaque occurrence and development and take appropriate intervention measures to prevent effectively cerebral infarction has very important significance.Materials and methods1.Clinical dataThe persons who are studied:100 patients from Dandong People's Liberation Army 230 Hospital,Department of Neurology,admitted with acute cerebral infarction (from January 2007～November 2008) in full compliance with the Fourth National Cerebrovascular Disease in 1995,the revised diagnostic criteria of academic conferences.Exclusion criteria:(1) repeated episodes of cerebral infarction;(2) valvular heart disease,atrial fibrillation,are caused by cerebral infarction;(3) cerebral vascular malformation,cerebral hemorrhage,brain trauma,vascular inflammation or blood disease,after cancer induced infarction;(4) diagnosed with head CT,brain CT showed a low-density shadow by a single stove cerebral infarction,two and two or more lesions were multiple foci of cerebral infarction.100 patients,male 65,female 35, age 60-94 years,from onset to treatment time for half an hour to 73 hours,50 cases with hypertension,type 2 diabetes were 41 smokers,37.Over the same period were 40 cases of out-patient health check as the control group,inclusion criteria for non-cerebrovascular disease,and all were confirmed by head CT to exclude cerebral infarction,22 males,18 females,aged 60-92 years old,with hypertension were 14,with diabetes mellitus type 2 were 10 smokers,10.Use the color Doppler ultrasound examination of carotid atherosclerosis,automatic biochemical analyzer for testing detailed record of blood lipids,blood glucose,serum uric acid,fibrinogen,at the same time we study the relationship between the high blood pressure,age,sex,smoking history and other relevant factors,Explore the relationship between the carotid atherosclerosis and the cerebral infarction.2.Experimental methods(1) Color Doppler ultrasonic diagnostic apparatus,respectively,in patients with carotid artery probe(CCA),common carotid artery bifurcation(BIF) and carotid artery (ICA) of extracranial observed in - in the film thickness(IMT) and wall diameter, carotid artery peak systolic velocity(SPV),resistive index(RI);in - the normal thickness of less than 1.0mm,larger than 1.2 mm to have plaque formation.According to color Doppler ultrasound of carotid artery plaque tips were divided into plaque group and non-plaque group. (2) The determination of blood biochemical indicators of an automatic biochemical analyzer units,cerebral infarction in the hospital,the healthy control group taking the examination on 12 h fasting venous blood 8 milliliters,centrifugal obtain plasma.Determination of glucose,total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein,serum uric acid,fibrinogen.Admitted to hospital the next morning quiet state manual mercury sphygmomanometer blood pressure three times the average mind.3.Statistical methodsMeasurement information and data to the mean±standard deviation((?)+S) that was used to compare T test orX~2 test;count data to the rate indicated,P＜0.05 indicated that differences are statistically significant.All the information using SPSS 13.0 software for statistical analysis.Experimental Results(1) The experimental group in the blood glucose,blood lipids,total cholesterol, triglyceride,low-density lipoprotein,serum uric acid,fibrinogen,hypertension, smoking history were higher,high-density lipoprotein less than the experimental group the two are statistically significant difference(P＜0.05).(2) in 100 patients with cerebral infarction in the carotid atherosclerotic plaque occurred with 85 cases,of which 70-79 plaque incidence of 32.94%,higher than the 60-69 years of age the incidence of 21.18%,while the 80-year-old above carotid atherosclerotic plaque incidence of the highest,45.88%.(3) cerebral infarction in 60 patients with single lesions in the left cerebral infarction and 18 cases of carotid artery atherosclerotic plaque occurred in the left in 13 cases,the lateral line with the rate of 72.22%,while the fight side of the 42 cases of cerebral infarction in and plaques on the right side of 34 cases,lateral line with the rate of 80.95%.(4) 60 cases of single lesions in patients with cerebral infarction,in which no plaque in 13 cases,accounting for 21.7%,with plaque group 47 cases,accounting for 78.3%;40 cases of multiple lesions in patients with cerebral infarction,non-plaque group 2 cases,5%,there are plaques in 38 cases,95%;and 40 cases of the control group,35 patients with no plaque,accounting for 87.5%,there are five cases of plaque group,accounting for 12.5%.ConclusionThe degree of carotid atherosclerosis is closely related with cerebral infarction, and high blood lipids,high blood sugar,high blood uric acid,fibrinogen increased, hypertension,male,smoking history and other carotid artery atherosclerosis risk factors, with age growth,degree of carotid atherosclerosis increased;carotid artery atherosclerotic plaque formation of other side do not have the same side of the relationship between the cerebral infarction.