High-risk Human Papillomavirus Detection In Clinical Research In The Follow-up Of Cervical Lesions

Objective: Through the dynamic observation of HPV, to explore the clinicalsignificance of the high-risk HPV testing in the follow-up of cervical intraepithelialneoplasia (CIN) and cervical cancer.Methords:Analysis327cases’ clinical data ofcervical intraepithelial neoplasia (CIN) and cervical cancer which were treated fromJanuary2010to December2012in our hospital,using dynamic detection of HPV(second-generation hybrid capture) and liquid-based cytology. to study the variation ofhigh risk HPV deoxyribonucleic acid viral loading, HPV clearance and the recurrencerate. Results:1.according to the research data, HR-HPV infection rate of cervicalintraepithelial neoplasia (CIN) and early cervical cancer was89.8%, no significantdifference between all levels’infection rates.2. Clearance of HR-HPV in cervical lesionsafter treatment was79.1%. CINI, CINII, CINIII and cervical cancer who’s HPV clearance(clearance rate) were87%,60.7%,81.6%,76.8%.at different levels, HR-HPV clearancerate are different. Cervical lesions always clear the HPV infection at six months aftertreatments.3. the viral load of HPV which was detected3months after treatment wassignificantly decreased than pre-treatment,the viral load of HPV overall downward trend.4.Cervical intraepithelial neoplasia (CIN) and cervical cancer mean time torecurrence(including uncontrollec VAIN) were16.3months,16.8months. Cervical lesionrecurrence rate was6.1%of of CINI, CINII, CINIII and cervical recurrence rate of3.8%,7.5%,3.5%, and10.8%. The high negative predictive value of HR-HPV HPV persistentinfection after treatment of cervical lesions intraepithelial neoplasia or cancer risk factorsfor recurrence of HPV joint TCT can increase the detection rate of recurrence of lesions.Conclusions: HR-HPV detection is very important in the follow-up of cervical lesions.The sustained HR-HPV infection are risk factors for recurrence.Persistent HPV-positivepatients should be given timely treatment to reduce the recurrence.