Expression And Significance Of The Level Of Peripheral Blood CD34Positive Cells In Patients With Acute Cerebral Infarction

Objective To evaluate the expression and clinical significance of the level ofperipheral blood CD133positive (CD133+) cells in patients with acute cerebral infarction；To explore the relationship of CD133positive expression with the patients’ clinicalinformation，and investigate the hypothesis that the level of circulating CD133positive ispredictive of risk factors for ischemic stroke.Methods A total of90individuals were examined，including60patients with acutecerebral infarction (infarct group，n=60)，60patients with cerebrovascular risk factors（control group, n=30). The EPC was marked byCD133+.The level of peripheral blood CD133+cells was determined byflow cytometry within72hours of onset of patients.The neural function defectscore and infarction lesion volume were determined in patients with infarction group.According to TOAST criteria, all the patients were classified into five subtypes：LAA、CE、SAA、SOE and SUE.Results （1）Compared with control group, the percentage of peripheral bloodCD133+cells in infarction patients is lower than which in the control group, the differencewas statistically significant (p<0.05)（.2）The percentage of peripheral blood CD133+cellswith different infarct lesion volume in infarction patients is significantly lower than thecontrol group, the difference was statistically significant (p<0.05);（3）The percentage ofCD133+cells in peripheral blood of patients with neurologic impairment score wasnegatively correlated (r=-0.755，p＜0.01).Conclusion The number of peripheral blood CD133+cells has correlation with therisk factors of cerebrovascular infarction.In cerebral ischemia, the level of peripheral blood CD133+cells is significant reduce and its level is related to neurologic impairmentand infarction volume. The level of circulating CD133+was predictive of neurologicalimpairment．...