Improvement Of Drug-associated Acute Interstitial Nephritis By Corticosteroids

Objective: To explore the effect of corticosteroids on Drug-Induced Acute InterstitialNephritis (AIN).Methods: A retrospective analysis of98patients with AIN mediated by drugsadmitted at the1stAffiliated Hospital of Chongqing Medical University, China. Thepatients are divided into2groups (treated group1and control group2) with49caseseach. According to their age, each group is divided into3age-groups (18-40,40-60and>60years) denominated A, B and C respectively. After admission, the two groups ofpatients were treated with diuretics, nutrition support therapy, correcting thehydro-electrolytic disorder or maintaining the acid-base balance and other symptomatictreatment. Besides these therapies, patients in treated group1received the therapy ofsteroids. The main clinical presentation, and blood and urinary analysis on the first dayof admission, the first, second,12thand24thweek were collected.Results: Improvement in Urea (BUN) and Creatinine (Cr) level as well as other signsand symptoms in treated group1was quicker than that in the control group2. Out of the49patients in the treated group1, only2developed CRF after24weeks, while6patients in the control group ended into CRF for the same period of time. The prognosisof old AKI patients (with age>60years old) in both treated and control groups waspoorer than that of the young and mid-aged patients. However, steroid treatment still tookeffect for the old patients.Conclusion: Most of the AIN patients treated without steroids may still recover tonormal. However, steroids help renal function to recover quickly, and the treatment maybenefit to maintain a good short-term as well as a long-term prognosis for AIN patients.