| Objective:To systematic review the effectiveness and safety of oxycodone/ acetaminophen for cancer pain.Method:PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CNKI, CBM, and Wanfang database were systematically searched from inception through June 30th,2014 with oxycodone/acetaminophen, cancer, pain, random and so on. Randomized controlled trials of oxycodone/acetaminophen for cancer pain were identified. And the methodological quality was assessed using the tool of risk of bias assessment by Cochrane. Data was analyzed using STATA 12.0 software.Results:A total of 28 RCTs were identified according to inclusion and exclusion criteria. The results of meta-analysis showed thatm The efficacy of oxycodone/actaminophen was better than placebo (RR=7.35; 95%CI:4.78-11.29; P<0.05).The efficacy of acetaminophen/oxycodone was slightly inferior to combined with Chinese and western medicine (RR=0.86; 95% CI:0.76 0.97; P<0.05), the difference was statistically significant, however, there were more incidences of dizziness, drowsiness, gastrointestinal reaction and patients with constipation and other adverse reactions (RR>1), there were no statistically significant differences..Compared with tramadol, acetaminophen/oxycodone could reduce the overall incidences of adverse reactions in terms of difference was statistically significant (RR=0.80; 95% CI:0.66 0.96; P<0.05), in addition, also can improve the total effective rate of pain relief (RR=1.04; 95% CI:0.96 1.13, P>0.05), slightly lower dizziness/drowsiness in the treatment process (RR=0.89; 95% CI:0.58 1.36, P>0.05), nausea/vomiting (RR=0.79; 95% CI:0.52 1.20, P>0.05), and constipation (RR=0.80; 95% CI:0.49 1.30, P>0.05), but there were no statistically significant difference.,,tacetaminophen/oxycodone was similar to oxycodone/hydrochloride for complete response rate (RR=0.99; 95% CI:0.92 1.06, P>0.05), however, acetaminophen/oxycodone caused higher incidences of dizziness/sleepiness (RR=1.35; 95% CI:0.60 3.06, P>0.05) and malignant/vomiting (RR=1.01; 95% CI:0.52 1.97, P>0.05). Compared with morphine sulfate, acetaminophen/oxycodone was better in pain (RR=1.03; 95% CI:0.931.13; P<0.05), the incidence of adverse reactions was also significantly lower (RR=0.31; 95% CI:0.22 0.42; P<0.05), particularly in the incidence of constipation (RR=0.15; 95% CI:0.04 0.60; P<0.05), and the differences were statistically significant, facetaminophen/oxycodone was more advantage than oxygen acetaminophen in cancerous pain analgesia (RR=1.18; 95% CI:0.99 1.41; P> 0.05), there was no statistically significant difference.pThe effective acetaminophen/oxycodone in treatment of cancer pain was better than ibuprofen stay for tablet (RR=1.1.3; 95% CI:0.91 1.39, p>0.05), but slightly inferior to double hydrogen codeine (RR= 096; 95% CI:0.75 1.24, p>0.05), there were no statistically significant difference.Conclusion:acetaminophen/oxycodone in alleviating cancerous pain of curative effect and reduce the adverse reaction of opioid drugs, improve the terminal cancer patients quality of life has been recognized by the majority of clinicians and patients.This included study quality was low and the quantity was less, would affect the authenticity and reliability of the results of the study. |
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