The Clinical Observation On The Combination Of Acupuncture And Decoction In Treatment Of Varicocele Infertility Patients With Kidney Deficiency And Blood Stasis

Background:Varicocele is in the plexiform spermatic venous plexus the emergence of the expansion,stretching,twisting. WHO has caused VC as the primary cause of male infertility. TCM holds that VC caused by the kidney deficiency and blood stasis. According to reported in literature and clinical Observation,both Chinese medicine treatment and acupuncture treatment could significantly improved the related abnormal parameters of the varicocele male infertility. However, effects of combination of acupuncture and decoction remains to be seen. The experiment was designed to verify the efficacy of combination of acupuncture and decoction in treatment of varicocele infertility.Objective:The objective is to observe the efficacy and safety of electric acupuncture and Tongluo Shengjing Decoction in treatment of varicocele infertility patients with kidney deficiency and blood stasis.Methods:This clinical study involved prospective, random methods, used controlled patient group.105patients who met the inclusion criteria were divided into acupuncture group (electric acupuncture combined with Tongluo Shengjing Decoction), Chinese medicine group (Tongluo Shengjing Decoction) and controlled group (Aescuvenforte), patients were randomly divided in a1:1:1ratio into each group,35cases per group. Selected cases been ruled out female factors and other causes of infertility. Composition of Tongluo Shengjing Decoction is:Radix Rehmanniae-cooked, Rhizoma Dioscoreae, fructus corni, Semen Cuscutae, fructus rubi, mulberry, herba epimedii, colla cornus cervi, astragalus mongholicus, codonopsis pilosula, ligusticum wallichii, angelica sinensis, radix paeoniae, carthamus tinctorious, cyathnla capitata Moq., pberetima. Above composition was made into granule decoction, advised patients to take1bag granules half an hour before breakfast and dinner. Electric acupuncture prescription was:ventral:Baihui, Qihai, Guanyuan, Guilai, Yinlingquan, Sanyinjiao, Taixi, Zusanli; dorsal:Genital area(SA), Geshu, Pishu, Shenshu, Diji, Xuehai, Shenmai, Zhaohai. Above prescription was given once per day, ventral and dorsal alternated,3-5times a week. Aescuvenforte was given2pills each time, twice a day, per oral. Course of treatment was3months, acupuncture and medicine combined group, Chinese medicine group and controlled group were given with one course of treatment each. Examinations:Observed before and after treatment progressive sperm (PR), amount of semen, sperm density, sperm livability rate(PR+NP), VSL, VCL, VAP, MAD, ALH, BCF, diameter of spermatic vein, normal sperm morphology. Safety indicators were:general physical examination/vital signs, blood and urine culture, liver and kidney function, electrocardiogram, etc..Results:During observation,1acupuncture and medicine combined group case exfilated;1Chinese medicine group case exfilated;2Controlled group exfilated,1case was excluded;100patients completed observation. Acupucture and medicine combined group, Chinese medicine group and controlled group total efficiency rates were85.3%,76.5%,68.8%; cured rates were23.5%,14.7%,9.4%; significant efficiency rates were44.2%,26.5%,21.9%; efficiency rates were17.6%,35.3%,37.5%; no efficiency rates were14.7%,23.5%,31.2%; there were significant difference between the clinical efficiency rates of three groups (P<0.05). After treatment, PR value of Chinese medicine group, acupuncture and medicine combined group and controlled group showed statistical significancy (P<0.05); there was significant statistical difference between before and after treatment PR between acupuncture medicine combined group and controlled group,(P<0.05); comparing the other groups showed no statistical significance (P>0.05); the PR mean difference between before and after treatment in Chinese medicine group and the controlled group showed no statistically significant (P>0.05), between the other two groups, the PR mean showed statistically significant difference (P&1t;0.05). Before and after treatment, acupuncture medicine combined group sperm density, PR+NP, VSL, VCL, VAP, MAD, left spermatic vein diameter, normal sperm morphology, semen volume, sperm density, and Chinese medicine group PR+NP, VSL, VCL, VAP, MAD, left spermatic vein diameter, the control group of sperm density, VAP, MAD showed statistical significancy (P<0.05); the controlled group semen dencity, VAO, MAD showed statistical significancy (P<0.05).Comparing after treatment results to controlled group, acupuncture medicine combined group semen volume, sperm density, PR+NP, VSL, VCL, VAP, MAD, spermatic vein diameter, normal sperm morphology, semen volume, sperm density and Chinese medicine group PR+NP, MAD showed statistical significancy (P<0.05); Comparing after treatment results to Chinese medicine group, acupuncture and medicine combined group VSL, VCL, VAP, MAD, normal sperm morphology showed statistical significancy (P<0.05).Conclusion:Electric acupuncture and Tongluo Shengjing Decoction combined treatment in kidney deficiency and blood stasis type varicocele infertility patients can significantly improve patients’ sperm density, PR, PR+NP, VSL, VCL, VAP, normal sperm morphology; decline MAD and left spermatic vein diameter, curative efficiency was better than those of Chinese medicine group (Tongluo Shengjing decoction) and controlled group (Aescuvenforte), there were no adverse events during and after treatment, therefore proved that acupuncture is a safe treatment.