Clinical Research On The Correlation Between Serum Bilirubin And Autherosclerotic Thrombotic Cerebral Infarction

Objective:To definite the correlation between serum bilirubin and autheroscleroticthrombotic cerebral infarctionMethod:We enrolled176aute autherosclerotic thrombotic cerebral infarctionpatients classified as cerebral infarction group and77non-acute cerebralinfarction (such as Myasthenia Gravwas, Peripheral Neuropathy, MotorNeuron Dwasease, Headaches, Benign Paroxysmal Positional Vertigo, etc.)patients classified as control group admitted to the first hospital of JilinUniversity,in the period between October2013and October2014. The clinicalinformation of both groups was collected and compwered in Statwastic inorder to clear the link between bilirubin and cerebral infarction includinggender, age, hypertension, diabetes, hyperlipidemia, smoking, drinking andserum bilirubin. The cerebral infarction group was examined by transcranialdoppler and color doppler ultrasound of the neck arteries. According to thedegree and number of vascular stenoswas, the cerebral infarction group wasrespectively invided into four groups and three groups and serum bilirubindivergence were analyzed among each group to define the relationship ofvascular stenos. According to if there was a previous infarction, cerebral infarction group was divided into two groups and serum bilirubin divergencewere analyzed between them to define the correlation between bilirubin andcerebral infarction recurrence. With one year for the sector, recurrent cerebralinfarction group was divided into two groups and serum bilirubin divergencewere analyzed between them to clarify the link between bilirubin andrecurrent time.Results:There was significant (P<0.05) difference in sex, hypertension, drinking,total bilirubin, direct bilirubin and indirect bilirubin between cerebralinfarction group and control group. There was negative correlation betweenindirect bilirubin and autherosclerotic thrombotic cerebral infarction. Totalbilirubin and direct bilirubin of normal group was significantly(P<0.05) higherthan mild stenosis group and moderate stenosis group. The total bilirubin,direct bilirubin and indirect bilirubin of multi-vessel stenosis group was(P<0.05) significantly lower than normal group and single-vessel stenosisgroup. There was significant (P<0.05) difference in gender, age, diabetes,total bilirubin, direct bilirubin and indirect bilirubin between first cerebralinfarction group and recurrent cerebral infarction group. The indirect bilirubin,gender negatively related to recurrence of cerebral infarction. There was nocorrelation between bilirubin and recurrent time.Conclusion:1. Low level of serum bilirubin is significantly related to cerebral infarction. Low level of serum indirect bilirubin, hypertension and drinkingare independent risk factors of autherosclerotic thrombotic cerebral infarction.2. Low level of total bilirubin and indirect bilirubin result in stenosis.3. Low level of serum bilirubin is significantly related to multi-vesselstenosis.4. Low level of serum bilirubin is significantly related to recurrentce ofcerebral infarction, but not to recurrentce time. Low level of indirect bilirubinis a independent risk factor of autherosclerotic thrombotic cerebral infarction.