The Research Of Plasma Level Of OX-LDL And Serum Lipids Content In Patients With Acute Cerebral Infarction From Different Altitudes

Objective: To investigate the changes of plasma oxidized low density lipoprotein(OX-LDL) and serum level of lipids in patients with acute cerebral infarction fromdifferent altitudes, discussing the change of OX-LDL and serum lipids functionamong cerebral infarction patients and healthy subjects at different altitudes.Materials and methods: To choose84patients with cerebral infarction,and accordingto the elevation divided into three groups, meanwhile healthy subjects were selectedas control. Plasma OX-LDL level were detected by ELISA method. Other related riskfactors including age, sex, and serum lipids level were also examined.Results: The different of plasma level of OX-LDL and serum lipids in cerebralinfarction groups in incidence of significance (P<0·05), and the plasma level ofOX-LDL in patients with cerebral infarction groups were significantly higher thannormal controls (P<0·01). The level of TC、TG and LDL in cerebral infarction groupswere also significantly higher than healthy controls (P<0·05). The level of HDL inpatient with cerebral infarction were gradually lower than control groups at differentaltitudes (P<0·01).Conclutions: Plasma level of OX-LDL are dramatically increased in the patients withacute cerebral infarction at different altitudes. Along with the rising of altitudes, thelevel of OX-LDL were rised up,thus OX-LDL may participate in the pathophysiologicprocess of cerebral infarction. TC、TG、LDL were risk factor for cerebral infarction.Within the rise of altitudes, the serum level of HDL were gradually lower, maybe it is a potential protective factor. In a word, HDL may decrease the risk of the cerebralinfarction.